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PubMed2006

Inhibitions of nucleus accumbens neurons encode a gating signal for reward-directed behavior.

The nucleus accumbens (NAcc) is critical in the control of goal-directed behavior. Pharmacological studies suggest that the NAcc may act in both instructive and permissive modes; however, previous electrophysiological studies in behaving rats have reported firing patterns consistent with an instructive, but not permissive, role for NAcc neurons. We now report that a subset of NAcc neurons shows a long-lasting inhibition in firing rate whose onset precedes initiation of goal-directed sequences of behavior and terminates at the conclusion of the sequence. Together with data from previous behavioral studies, this firing pattern suggests that, when active, these neurons tonically inhibit appetitive and consummatory behaviors and that, when inhibited, these neurons permissively gate those behaviors.

Animals↗
PubMed2006

Stereotyping and evaluation in implicit race bias: evidence for independent constructs and unique effects on behavior.

Implicit stereotyping and prejudice often appear as a single process in behavior, yet functional neuroanatomy suggests that they arise from fundamentally distinct substrates associated with semantic versus affective memory systems. On the basis of this research, the authors propose that implicit stereotyping reflects cognitive processes and should predict instrumental behaviors such as judgments and impression formation, whereas implicit evaluation reflects affective processes and should predict consummatory behaviors, such as interpersonal preferences and social distance. Study 1 showed the independence of participants' levels of implicit stereotyping and evaluation. Studies 2 and 3 showed the unique effects of implicit stereotyping and evaluation on self-reported and behavioral responses to African Americans using double-dissociation designs. Implications for construct validity, theory development, and research design are discussed.

Adult↗
PubMedDate not supplied

Restraint as misregulation in drinking and eating.

The present study was designed to increase our understanding of the co-morbidity between problem drinking and binge eating. The study investigated both consummatory behaviors in relation to restrained drinking, restrained eating, and a general measure of self-control. The participants were a sample of 658 boys and 414 girls aged between 14 and 17 years. The dimension of restraint, which best predicted the two problem behaviors when examined separately for both boys and girls, was cognitive and emotional preoccupation (CEP) about controlling one's consummatory intake. In addition, evidence was found linking both problem drinking and binge eating to restraint and poor general self-control. The struggle with self-control and the high emphasis on CEP about controlling one's consummatory intake, which characterise restrained drinking and restrained eating, closely resembles Baumeister and Heatherton's notion of misregulation [Psychol. Inquiry 7 (1996) 1.]. Discussed are the similarities between restraint and misregulation, and the kinds of strategies that can be used to improve self-control.

Adolescent↗
PubMed2006

Volume and dose effects of experimenter-administered ethanol preloads on ethanol seeking and self-administration.

The present experiment used a behavioral model developed to separate the initial behavior required to obtain access to ethanol (appetitive responding or lever presses) from the actual self-administration (consummatory responding or intake) to test the hypothesis that these responses are under the control of different behavioral/physiological processes, and therefore differentially affected by an ethanol priming dose. In male, Long Evans rats, "preload" volume (0.5 and 2.0ml) and dose (approximately 10%, 25%, and 50% of the total normally consumed in nontreatment sessions translating to 0.1, 0.25, and 0.5g/kg) of ethanol were varied and administered by the experimenter via oral gavage prior to an operant session. Overall, there were no priming effects, or increases, in ethanol-reinforced responding resulting from the ethanol preloads. The findings showed that the low preload volume produced linear, dose-dependent decreases in both intake and seeking. However, while the high volume also produced a linear dose-dependent decrease in ethanol seeking, there was a decrease in intake at every dose. That is, ethanol seeking was insensitive to preload volume, while intake was affected in a dose-dependent manner except at the lowest dose when preload volume did play a role in intake regulation. These findings indicate that "fullness" and pharmacological cues differentially impact the appetitive and consummatory behaviors reinforced by ethanol solutions, with intake being more sensitive to preload volume and seeking being more sensitive to preload pharmacology.

Alcohol Drinking↗
PubMed2004

Motivation concepts in behavioral neuroscience.

Concepts of motivation are vital to progress in behavioral neuroscience. Motivational concepts help us to understand what limbic brain systems are chiefly evolved to do, i.e., to mediate psychological processes that guide real behavior. This article evaluates some major motivation concepts that have historic importance or have influenced the interpretation of behavioral neuroscience research. These concepts include homeostasis, setpoints and settling points, intervening variables, hydraulic drives, drive reduction, appetitive and consummatory behavior, opponent processes, hedonic reactions, incentive motivation, drive centers, dedicated drive neurons (and drive neuropeptides and receptors), neural hierarchies, and new concepts from affective neuroscience such as allostasis, cognitive incentives, and reward 'liking' versus 'wanting'.

Animals↗
PubMed2005

Striatal muscarinic receptor antagonism reduces 24-h food intake in association with decreased preproenkephalin gene expression.

Cholinergic interneurons of the striatum respond to motivationally relevant stimuli and are involved in appetitive learning. However, there has been relatively little inquiry into the role of striatal acetylcholine in food motivation. Here we show in rats that a single infusion of the muscarinic receptor antagonist scopolamine (0, 5.0 or 10.0 microg/0.5 microL bilaterally) potently reduced 24-h food intake following injections into either the ventral or dorsal striatum, without affecting water intake. Furthermore, muscarinic receptor blockade induced reliable and widespread reductions in striatal preproenkephalin, but not preprodynorphin, mRNA expression. These data suggest a novel role for striatal acetylcholine in modulating feeding behavior via its effects on enkephalin gene expression. As prior research indicates a critical role for striatal enkephalin in consummatory behaviors and palatability, we hypothesize that cholinergic interneurons assist in translating hypothalamic energy state signals into food-directed behaviors via their regulation of striatal opioid peptides.

Animals↗
PubMed1980

Behavioral effect of selective and non-selective lesions of median raphe nucleus in the rat.

The role of the serotonergic (5-HT) system in the regulation of locomotor activity and consummatory behaviors was studied. Electrolytic and chemical (5,7-dihydroxytryptamine: 5,7-DHT) lesions were made in the median raphe nucleus (MR). The effects of these lesions on spontaneous locomotor activity, food and water intake and body weight were then studied. In these experiments, rats on an ad libitum feeding-drinking regimen were housed individually in cages with activity wheels located in a room kept at a temperature of 22 + 1 degrees C. For each rat, records were kept of its spontaneous locomotor activity, food and water intake, and body weight for 8 weeks before and after the placement of lesion in MR. It was observed that: (1) electrolytic destruction of the MR produced a permanent decrease in locomotor activity, and (2) there were a reduced food intake and a decreased spontaneous activity after intra-MR injection of 5,7-DHT.

Animals↗
PubMed2004

Effects of raclopride in the core of the nucleus accumbens on ethanol seeking and consumption: the use of extinction trials to measure seeking.

BACKGROUND: A previous study using a sipper procedure of ethanol self-administration found that blockade of the D2 dopamine (DA) receptors in the nucleus accumbens resulted in a reduction in ethanol-seeking behavior with only slight effects on ethanol drinking. However, because of procedural matters in that study, it was unclear as to the extent of the reduction in seeking behavior that occurred. This study expanded that study to examine in more depth the role of DA transmission in the nucleus accumbens in ethanol-seeking and consummatory behaviors. METHODS: Male Long-Evans rats were initiated to self-administer 10% ethanol with a sipper-tube procedure. Once initiated, in a once-a-day session, pressing a lever 30 times resulted in a sipper tube containing the ethanol solution being made available for 20 min. By using extinction trials in which no sipper was presented and responses were recorded for 20 min, a measure of ethanol seeking, with no effects of consumption, could be obtained. Bilateral microinjections of 1.0, 3.0, and 10.0 microg of raclopride into the nucleus accumbens were tested on both consummatory and extinction trials. RESULTS: There were significant decreases in ethanol-seeking responses at both the 3.0- and 10.0-microg doses of raclopride, whereas no effects of those doses on consumption were observed. The effects on extinction responding were the same for the first run of responses as for total responding, without effecting rates of responding. CONCLUSIONS: These findings replicate and expand the initial study with this model of ethanol self-administration and indicate that DA transmission at the D2 receptor in the nucleus accumbens is important for processing information related to stimulus control and goal-directed behavior. The results also suggest that DA has at most a minor role in controlling ethanol consumption once a drinking bout has begun.

Alcohol Drinking↗
PubMed2001

Effects of acamprosate on ethanol-seeking and self-administration in the rat.

BACKGROUND: Acamprosate (calcium acetyl homotaurinate) has been used clinically to treat relapse in alcoholics. In rats, it has been shown to decrease ethanol, but not water, self-administration after ethanol deprivation. METHODS: To further investigate the effect of acamprosate on reinforced behaviors in rats, the present experiment used: (1) both ethanol and sucrose reinforcer solutions to better assess the distinct effects of acamprosate on ethanol-directed behaviors, and (2) an operant model that procedurally separates the "cost" to begin drinking from consuming the reinforcer solutions to dissociate the effects of acamprosate on appetitive versus consummatory processes. In daily sessions (5 days/week), rats (n = 6/group) were trained to make 30 lever-press responses to gain access for 20 min to a sipper tube containing either ethanol (10%) or sucrose (3%). After stable responding, acamprosate treatment was given. Three doses were tested (50, 100, and 200 mg/kg/injection, intraperitoneally), one dose per week. Each week, a total of four injections were given (21 and 2 hr before the operant sessions over 2 consecutive days). RESULTS: At these doses, acamprosate had no effect on the measures of appetitive responding for either solution. However, all doses reliably decreased ethanol consumption on the 2nd day of treatment (from an average of 0.83 to 0.63 g/kg). Analysis of the pattern of ethanol consumption showed that the effects of acamprosate occurred after the onset of a normal pattern of intake, as measured by lick rate and size of the initial bout of drinking, which suggested that acamprosate is most effective when combined with the pharmacological effects of ethanol. Sucrose intake was unaffected by all acamprosate treatments, which indicated that the treatment effects were specific to ethanol and not due to a general decrease in consummatory behavior. CONCLUSIONS: Overall, these results suggest that acamprosate is effective at reducing total ethanol intake, but may not reliably alter subjects propensity to begin a drinking bout as measured by this model. However, whether this applies to the clinical use of acamprosate, where other types of reinforcement may also precipitate relapse drinking, is not certain.

Acamprosate↗
PubMed2006

Decline in hippocampal theta activity during cessation of locomotor approach sequences: amplitude leads frequency and relates to instrumental behavior.

Hippocampal theta frequency and amplitude decrease as locomotor approach slows and the goal is reached. This study compared the declines of these theta parameters and related them to behavioral events. Theta activity was recorded with bipolar electrodes spanning cornu Ammon, sector 1 or cornu Ammon, sectors 2/3 cell layers of the dorsal hippocampus in 12 rats trained to approach and depress a treadle which exposed a milk dipper. Behavioral events were identified using a video capture system (20-ms sampling) synchronized to the hippocampal recording system (10-ms sampling). Peri-event averages of theta activity were made around the initial paw contact with the treadle, the presentation of the dipper, and the first lick at the dipper. Phase relationships between averaged hippocampal slow wave activity and behavioral events occasionally were found but they were inconsistent. In averages of both amplitude and frequency, times of minimum were less variable around paw contact indicating that compared with reward presentation and consummatory behavior, it more closely related to the processes determining the declines. Theta amplitude declined more rapidly than frequency and reached an earlier minimum in averages around initial paw contact and dipper presentation. Mean amplitude minimum occurred after the paw contact at 159 ms but the decline of frequency continued into the licking bout with its minimum occurring at 343 ms. The findings indicate that during the termination of approach locomotion, the amplitude of hippocampal theta activity is closely related to specific expected sensorimotor events.

Action Potentials↗
PubMed2000

Nicotine induces disinhibitory behavior in the rat after subchronic peripheral nicotinic acetylcholine receptor blockade.

The present study investigated the effects of subchronic nicotine, mecamylamine and hexamethonium, alone or in combinations, on locomotor activity and behavioral inhibition. Rats were divided into groups and tested for locomotor activity after acute nicotine. The different groups received vehicle, nicotine, mecamylamine, mecamylamine+nicotine, hexamethonium (two different concentrations) and hexamethonium+nicotine injections once a day for 15 days after which they were tested for nicotine-induced locomotor activity again. Acutely, nicotine stimulated locomotor activity, and repeated daily nicotine or hexamethonium+nicotine administration sensitized the animals to this nicotine-induced locomotor stimulation (locomotor sensitization). Mecamylamine administered subchronically in combination with nicotine was able to block the induction to locomotor sensitization to nicotine. None of the nicotinic receptor antagonists induced locomotor sensitization to nicotine by themselves. In the elevated plus-maze, subchronic nicotine treatment demonstrated a nicotine-induced behavioral disinhibition, measured as an increase of time spent in and entries made into open arms. In contrast to the findings regarding locomotor sensitization, none of the antagonists counteracted the induction of this nicotine-induced behavioral disinhibition after subchronic co-treatment with nicotine. In addition, both antagonists by themselves produced a similar effect as subchronic nicotine, i.e. promoted the development of nicotine-induced disinhibitory behavior. It was concluded that the induction of locomotor sensitization to nicotine involves stimulation of central nicotinic acetylcholine receptors, whereas the development of nicotine-induced behavioral disinhibition involves blockade of peripheral nicotinic acetylcholine receptors, and that the latter, but not the former, phenomenon from a pharmacological point of view appears to be related to the increased ethanol consummatory behavior observed after subchronic nicotine administration.

Animals↗
PubMedDate not supplied

Effects of calcitonin gene-related peptide on food intake.

Recently, calcitonin gene-related peptide (CGRP), a product of alternative processing of RNA transcripts from the calcitonin gene, has been characterized. CGRP is present in a number of areas of the brain involved in modulating ingestive behaviors. We tested the effect of centrally administered CGRP on ingestive behaviors. ICV CGRP over a dose range of 1 to 10 micrograms suppressed food intake in 24 hr deprived rats and 20 and 10 micrograms decreased spontaneous nocturnal food intake. CGRP was less effective than calcitonin at suppressing food intake. Peripheral CGRP was less effective than centrally administered CGRP. Behaviorally, CGRP treated animals rested more, groomed less and ate less. Central CGRP (10 micrograms) did not alter circulating glucose levels. These results suggest that CGRP in high doses may be centrally active in regulating consummatory behaviors.

Animals↗
PubMed1996

Enforced water drinking induces changes in burying behavior and social interaction test in rats.

The effect of water deprivation and water intake on experimental anxiety in rats was tested using burying behavior (BB) and social interaction (SI) anxiety paradigms. Two groups of animals were studied: a control group with free access to water, and a 72-h water-deprived experimental group. Anxiety was studied in a water-deprived group or following a 10-min period of ad lib water drinking. An increase in the mean time of defensive burying in animals deprived for 72 h was observed, whereas an important reduction occurred in the levels of burying behavior immediately after the animals were allowed to drink ad lib for 10 min. These results suggest that the observed increase in defensive burying in the water-deprived animals represents an anxiogenic effect, whereas the decrease in this behavior in water-satiated animals is considered an anxiolytic action. The temporal course of reduction in burying behavior, observed after water drinking, revealed that the anxiolytic action lasts 5 min, whereas 15-30 min after drinking, burying behavior levels were similar to those in the control group. In the social interaction experiment a partial anxiogenic/anxiolytic effect of water deprivation and water intake was observed. The adaptive meaning of anxiogenic and anxiolytic changes linked to consummatory behaviors in rats is discussed on the basis of behavioral and biochemical data.

Animals↗
PubMed1993

An assessment of the interaction between cholecystokinin and the opiates within a drug discrimination procedure.

Recently, cholecystokinin (CCK) has been reported to antagonize a variety of opiate-induced effects, including nociception, body shaking, thermoregulation, and locomotion. Consistent with these results, a number of CCK antagonists potentiate the opiates in a range of behavioral and physiological assessments. The present study further examined the interaction between CCK and the opiates within the conditioned taste aversion baseline of drug discrimination learning, a design that utilizes the stimulus properties of the drug to control consummatory behavior. Specifically, animals injected with CCK prior to saccharin-LiCl pairings and the CCK vehicle prior to saccharin alone rapidly acquired the CCK-vehicle discrimination, avoiding saccharin consumption following the administration of CCK and consuming the same saccharin solution following the vehicle. Although the stimulus properties of CCK did not generalize to either naloxone or diprenorphine, morphine blocked and naloxone potentiated CCK's stimulus effects. These data are thus consistent with a physiological (rather than a pharmacological) interaction between CCK and the opiates.

Animals↗
PubMed1992

Scheduled running wheel activity indexes the specificity of pharmacological anorexia.

Nondeprived male Sprague-Dawley rats that were given scheduled access to running wheels for 60 min daily ran immediately and energetically. Intraperitoneal injections of 400 micrograms/kg pancreatic glucagon and 0.15 microgram/kg cholecystokinin octapeptide had no effect on scheduled running, but significantly inhibited feeding when the rats were offered condensed milk instead of access to the running wheels. This is consistent with the hypothesized function of these peptides as postprandial satiety signals. In contrast, 0.5 mg/kg amphetamine and 75 microM/kg LiCl, which produced similar degrees of anorexia, inhibited running by about 50%. Amphetamine, but neither peptide, also inhibited water drinking and disrupted the behavioral sequence of postprandial satiety. The distance run during scheduled running tests was inversely related to body weight, but the patterns of the drugs' effects were not altered by baseline running differences. Scheduled wheel running is a robust consummatory behavior that appears to provide a relatively valid, simple, and sensitive test of the behavioral specificity of pharmacological anorexia.

Amphetamine↗
PubMed1991

Opportunities for treatment of psychoactive substance use disorders with serotonergic medications.

The authors review both the preclinical and the clinical evidence for a role of serotonin (5-HT) systems in the regulation of drug-taking behavior. Animal studies show that pharmacologic treatments that enhance 5-HT function, notably selective reuptake inhibitors, reduce the self-administration of a variety of substances of abuse, including ethanol and cocaine. These treatments also tend to suppress consummatory behavior in general. In contrast to the broad spectrum of suppression following 5-HT enhancement, selective antagonists at the 5-HT3 receptor subtype have been reported to reduce ethanol but not cocaine or food intake. Although essentially limited to alcohol abusers, clinical studies seem to support the preclinical findings that a number of 5-HT reuptake inhibitors decrease interest in and intake of alcohol in mild-moderate ethanol-dependent individuals. Furthermore, other serotonergic drugs may show utility in the treatment of alcohol abuse. Another way in which serotonergic medications can be used in treating substance abuse is by the treatment of comorbid psychoactive illness for which such drugs are already known to be effective, e.g., depression and anxiety disorders.

Alcoholism↗
PubMed1988

Isolation-dependent enhancement of 2-[14C]deoxyglucose uptake in the forebrain of zebra finch males.

In a previous study (H. J. Bischof & K. Herrmann (1986), Behavioral Brain Research, 21, 215-221) we demonstrated that four forebrain areas of the zebra finch male are activated in situations which arouse the animal, for example when the birds are chased around the cage or when they are exposed to a female. These areas, the hyperstriatum accessorium-dorsale (HAD), a part of the medial neo-hyperstriatum (MNH), the lateral neo-hyperstriatum (LNH), and a portion of the caudal archi-neostriatum (ANC), show enhanced 2-[14C]deoxyglucose (2-DG) uptake according to the experimental situation. On the basis of these experiments, we examined whether the activation of the areas is correlated with motor activity and is influenced by different isolation times prior to a 2-DG experiment, where courtship of the male birds is elicited by exposing them to a female zebra finch. For this purpose, we isolated male zebra finches for 1 day, 1 week, or 8 weeks, respectively, before we injected the 2-DG and exposed the birds to a female. During the experiment, besides other activities, the number of song motifs performed by the bird and the frequency of changing perches was recorded. Our experiments demonstrate that there is a weak negative correlation between motor activity and 2-DG uptake, and a positive correlation between isolation time and 2-DG uptake. We suggest that long isolation blocks courtship behavior by some unknown mechanisms, and that the "internal drive" of the animal, which possibly corresponds with the activity of the four forebrain areas, is enhanced by isolation and by the fact that the birds do not perform the consummatory behavior. Our results also demonstrate that the 2-DG method can show up small differences in the internal state of an animal, which cannot easily be detected by behavioral measurements.

Animals↗
PubMed1983

Postpartum behavior in the mouse: the contribution of suckling stimulation to water intake, food intake and body weight regulation.

Rockland-Swiss (R-S) Albino female mice that receive suckling stimulation from young consume significantly more water and food and gain significantly more weight than dams without young. Excision of nipples (thelectomy) prevents postpartum increases in these consummatory behaviors and in body weight gain even in dams with extensive prior suckling exposure. Thus, both the initiation and maintenance of postpartum ingestive behaviors depend primarily upon suckling stimulation from young.

Animals↗