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PubMedDate not supplied

[Control of laser treatment of 58 cervical condylomas: cyto-colposcopic correlations at 3, 6 and 12 months].

Cytologic and colposcopic findings 3, 6 and 12 months after laser treatment of cervical condyloma or intraepithelial neoplasia have been studied. Cytologic features of Papillomavirus infection were evidenced in 28 cases by cytology but only in 12 by colposcopy. The cytologic most frequent feature was parakeratosis without clear koilocytosis. One year after laser treatment, cytology and colposcopy showed features of papillomavirus infection in only seven cases. Thus, spontaneous regression of colposcopically detected lesions occurred in five cases. In 16 cases, the parakeratosis detected on the first smear seem to represent healing and tissue maturation more than the persistence of HPV infection.

Adult↗
PubMed1989

Condylomatous lesion (HPV infection) of uterine cervix. A clinical, colposcopic, cyto, histomorphological and immunohistochemical study.

43, patients, subjected to cervical cytology, colposcopy and colposcopic directed biopsy, were found to have lesions suggestive of human Papillomavirus (HPV) infection by one or more parameters. Immunohistochemical staining for HPV antigen yielded positive results in 23 (53.5 p. cent) cases. Amongst 30 cases with HPV lesions both in cytology and histopathology, 19 (63.3 p. cent) were positive for the HPV antigen. This was significantly higher as compared to the groups where HPV lesion was observed in cytology or histology alone (p = 0.05). The rate of positivity was the highest (81.3 p. cent) in a group of 16 patients having low grade dysplasia (mild to moderate) and both cytology and histologic evidence of koilocytotic changes. Presence or absence of HPV lesion by colposcopic examination in these 43 cases did not make any significant difference in rate of antigen positivity.

Adult↗
PubMed1989

Colposcopic assessment in microinvasive carcinoma of the cervix.

Forty of the 87 patients with microinvasive carcinoma (MIC) of the uterine cervix who underwent surgery were diagnosed colposcopically and the results were compared with the cytological and histological diagnoses. The cytology showed preinvasive carcinoma in 20 (50.0%) patients and invasive carcinoma in 19 (47.5%) patients. A correct colposcopic diagnosis was made in nine (22.5%) patients as having microinvasive carcinoma, 21 (52.5%) patients preinvasive carcinoma and eight (20%) patients invasive carcinoma, to sum up accuracy rate as 32.1%. The abnormalities most commonly observed in colposcopy were mosaic, punctuation and white epithelium. In microinvasive carcinoma, the triad co-existed in 43% of the patients. Atypical vessels, characteristic of invasion, were found in only one third of the patients. Microinvasion, therefore, may not be evident on colposcopy alone. It is therefore necessary to apply cone biopsy, prior to definite therapy, to make an accurate assessment of the maximum depth and extent of the invasion prior to definitive therapy.

Biopsy, Needle↗
PubMed1987

Colposcopic features of papillomaviral infection and premalignancy in the female lower genital tract.

Colposcopy plays an important role in the investigation and direct management of papillomavirus infection of the female lower genital tract. The colposcopic appearances of subclinical papillomavirus disorders resemble intraepithelial neoplasia, and the matter is further confused in that subclinical lesions are often accompanied by intraepithelial neoplasia into which they grade with indefinite borderlines. High accuracy in prediction of histologic diagnosis in the spectrum that ranges from subclinical papillomavirus infection to major grades of intraepithelial neoplasia may be achieved by a system of grading of colposcopic appearances.

Cell Transformation, Viral↗
PubMed1988

Sjögren's syndrome: clinical, cytological, histological and colposcopic aspects in women.

Sjögren's syndrome, characterized by a progressive alteration of the exocrine glands which ultimately results in their atrophy, has the highest incidence among females. The main etiopathogenetic mechanism is autoimmunological. The symptomatology is made up of symptoms depending on an altered glandular secretion and mucosal dryness. Dyspareunia and pruritus, due to vaginal and vulvar dryness, are quite common symptoms. Few studies have considered the clinical and histological consequences of Sjögren's syndrome in the external female genitalia. In the present study 26 women (mean age 46 years) affected by Sjögren's syndrome were examined by means of a series of tests including gynecological examination exam, colposcopic inspection and cervical biopsy. All the patients showed a particular dryness a series of tests including gynecological examination failed to evidence malign cells and, in 15% of the subjects, showed an estrogenic insufficiency in various degrees. The colposcopic inspection revealed dystrophic processes resulting in the atrophy of the cervico-vaginal mucosa in 50% of the cases. The histological findings of the cervical biopsies evidenced the presence of a chronic cervicitis in 10% of the cases.

Adult↗
PubMed1988

Comparison of suspicious and positive colposcopic, cytologic, and histologic findings in the uterine cervix.

One hundred and seven cases of suspicious or positive colposcopic or cytologic findings were histologically analyzed. In cases of colposcopically detectable, atypical changes or suspicious findings as well as of cytologic dysplasias or carcinomas, the histologic diagnoses were almost the same. The results demonstrated that colposcopy and cytology with a quick staining method are of value. Biopsy can quickly follow in cases of suspicious findings.

Colposcopy↗
PubMed1985

Incidence of dysplasia, carcinoma in situ and invasive carcinoma in colposcopic findings of atypical re-epithelization zone (A.R.Z.) and atypical transformation zone (A.T.Z.).

The Authors report their experience on 5518 colposcopic examinations and consider especially the findings of A.R.Z. and A.T.Z. and the correlation with cytologic and histologic aspects. They found a significant incidence of CIN (I, II, III) and invasive carcinoma by means of association of directed punch biopsies under colposcopic vision. Finally the importance of histological examination also in presence of negative cytologic findings is evidenced.

Adolescent↗
PubMed1985

Colposcopic accuracy in the diagnosis of microinvasive and occult invasive carcinoma of the cervix.

One hundred eighty patients with microinvasive and occult invasive squamous cell carcinoma of the cervix who were examined by colposcopy during a ten-year period are reviewed. Forty-two percent of patients with microinvasive carcinoma and 28% of patients with occult invasive carcinoma had an unsatisfactory colposcopic examination. Colposcopy led to the correct management in 90% of patients with occult invasive cancer and in 84% of patients with microinvasive carcinoma. Colposcopy appeared to be less sensitive in detecting microinvasive lesions than in detecting occult carcinoma. Two-thirds of the errors made were colposcopist-related, either failure of interpretation or protocol violation. A small but definite group of patients will have lesions whose colposcopic appearance is not sufficiently distinct or characteristic to permit a diagnosis of early invasion.

Adult↗
PubMed1978

Duration of colposcopic changes associated with trichomonas vaginitis.

The possibility that an abnormal Papanicolaou smear of the uterine cervix may be associated with vaginitis due to trichomonas vaginalis has been known for some time. Since colposcopy is being used with increased frequency to evaluate patients with cytologic abnormalities noted on the cervical smear and the colposcopic changes produced by trichomonal vaginitis are quite typical, a study was designed to evaluate the duration of these changes after effective eradication of the parasite. Among 12 patients in whom the infection was successfully treated, none showed evidence of colposcopically detected abnormalities due to the trichomonal vaginitis at 2 weeks and again at 4 weeks after initiation of therapy.

Adult↗
PubMed1984

A colposcopic and histological study of experimental chlamydial cervicitis in marmosets.

A total of 14 marmosets were inoculated intra-vaginally with Chlamydia trachomatis and the development of genital tract disease was assessed microbiologically, by colposcopic examination of the cervical and vaginal mucosa and by cytological and histological examination of biopsy and autopsy specimens. Eight animals had infections which persisted microbiologically for 2-5 weeks, and six animals, three of which had been inoculated on multiple occasions in a previous study, apparently eliminated their infection within 1 week of inoculation. Colposcopic examination showed that four of the eight infected animals developed acute cervicitis characterized by erythema, occasional slight oedema, and the presence of cloudy or purulent cervical mucus. The other four infected animals showed minimal signs of cervical inflammation. Three of the six animals which rapidly cleared their infections developed slight cervical inflammation characterized by erythema and cloudy cervical mucus during the fortnight after inoculation. Six control animals inoculated with medium displayed minimal cervical changes. The diagnosis of acute cervicitis in the infected animals was confirmed by examination of histological sections and cervical smears, which revealed the presence of polymorphonuclear leucocytes, with lymphocytes occasionally being seen. Although inflammatory changes were occasionally noted in specimens from control animals, the changes were relatively mild and occurred at a later time than those seen in infected animals. Intracytoplasmic chlamydial inclusions in epithelial cells were not detected in any of the specimens studied. Examination of genital tract tissue obtained at autopsy from five inoculated animals generally showed inflammation of the cervix and vagina, but in only one of these animals was there evidence of endometriosis and salpingitis.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Comparison of suspicious and positive colposcopic, cytologic and histologic findings in the uterine cervix.

One hundred thirty-five cases of suspicious or positive colposcopic or cytologic findings were histologically analyzed. In cases of colposcopically detectable atypical changes or suspicious findings as well as of cytologic dysplasias or carcinomas, the histologic diagnoses were almost the same. The results demonstrated that colposcopy and cytology with a quick staining method are of value. Biopsy can quickly follow in cases of suspicious findings.

Biopsy↗
PubMed1984

Colposcopic findings in virgin and sexually active teenagers.

The colposcopic findings in 86 virgin teenagers are reported and compared with a matched control group of 172 sexually active teenagers. The results show that an atypical transformation zone may be observed in virgins and that the prevalence rate of this condition is different when compared with that of sexually active teenagers. These data suggest that: 1) the presence of a colposcopically observed atypical epithelium is due to a normal maturation process occurring in young women after the menarche, and 2) coitus is responsible for the prolongation of this process in sexually active teenagers.

Adolescent↗
PubMed1983

Colposcopically directed conization for frozen-section examination in the management of cervical intraepithelial neoplasia.

We found colposcopically directed conization for frozen-section (F/S) examination to be 100% accurate in ruling out the presence of invasive cervical carcinoma. Therefore, the definitive treatment for cervical intraepithelial neoplasia (CIN)--hysterectomy in women who do not want more children--could be performed while the patient was still under the anesthetic used during procurement of the conization specimen. This technique reduces the risk of using anesthesia a second time and also reduces the costs of CIN treatment. Colposcopically directed conization should be done by experienced colposcopists only.

Adult↗
PubMed1983

The "unsatisfactory" colposcopic examination.

One hundred nine of 735 patients (14.8%) referred for colposcopic evaluation had "unsatisfactory" examinations. Of 108 women 40 years of age or over, 81 had unsatisfactory examinations (45%) as compared with 28 of 555 women under 40 (5%) (p less than 0.001). Thirty-five of the 109 patients with unsatisfactory examinations (32%) had had prior cautery or conization as compared with 141 of 626 in the "satisfactory" group (22.5%) (p less than 0.04). Seventy-three of the 99 patients on whom follow-up information was obtained had cervical conization biopsies for final diagnoses. Correlation with previously performed endocervical curettage and colposcopically directed biopsies was poor. Careful correlation of cytology, colposcopy and histopathology is necessary to achieve optimal results in the management of patients with unsatisfactory examinations. Diagnostic conization continues to play an important role in the management of patients with abnormal cervical cytology.

Adult↗
PubMed1981

Benign pictures of the uterine cervix in a large colposcopic survey.

The Authors have examined the results of 14.703 colposcopic examinations performed at the Social Medicine Center of the Province of Florence between 1974 and 1978, grouping the women according to childbearing and age. The purpose was to verify if mechanical and traumatic factors related to delivery may be responsible for modifications of the epithelial lining of the uterine cervix and especially for ectopy. The Authors have shown that the percentage of incidence of colposcopic picture of portio with original squamous epithelium and ectopy maintain almost identical values in nulliparae and pluriparae. Delivery does not significantly influence the presence of ectopy: the slight increase of such a picture in pluriparae is attributed to the formation of "ektropion", and the Authors define this picture, clearly separating it from the ectopy picture. The presence of ectopy decreases considerably as the women's age increases: this is attributed to therapeutic treatments possibly undergone over the years and to the spontaneous mending processes which are completed with age. Ectopy and its typical transformation zones are found in high percentages in the age group of women under 20. This corresponds exactly to the percentages reported by a few Authors on the presence of jodonegative zones in newborns. On the basis of these results, the Authors conclude that delivery does not modify the condition of the uterine cervix and deny any relation between traumatic factors and "cervical erosion".

Adolescent↗
PubMed1981

Accuracy of colposcopically directed biopsy in patients with cervical neoplasia.

The histologic diagnoses of premalignant and malignant lesions of the cervix obtained by examining the colposcopically directed biopsy material from 643 patients were compared with those of the surgical material subsequently obtained. The procedures during which samples were acquired included hysterectomy (370), cervical conization (263), cervical amputation (2), and removal of a retained cervical stump (8). The diagnostic accuracy of colposcopically directed biopsy was 93.0% in those patients with satisfactory colposcopy, ie, the final diagnosis did not differ by more than 1 grade from that of the directed biopsy diagnosis. Two patients with widespread stage III cervical intraepithelial neoplasia on directed biopsy had microinvasive carcinoma in the therapeutic cone specimen. All invasive carcinomas (stage IB, occult) were diagnosed by directed biopsy and confirmed by subsequent examination of the surgical specimen.

Adolescent↗
PubMed1981

[Role played by colposcopic specimen biopsy for elucidation of cervical intra-epithelial neoplasia (CIN) (author's transl)].

An account is given in this paper of the importance of colposcopic specimen biopsy to the diagnosis of cervical intra-epithelial neoplasia (CIN). Colposcopically controlled specimen biopsy was performed on 235 women who were either conisised or hysterectomised, eight weeks later. - The histological findings obtained from these biopsies were compared with the results recorded from definite histological examination, with complete agreement being established in 152 cases or 64.7 per cent. Biopsy results were more severe in 41 cases or 17.4 per cent. This was considered to be correct assessment, too. Hence, correct forecasts were made in 82.1 per cent of all cases under review. Cases were underestimated in 42 instances or 17.9 per cent. Specimen biopsy was in no case followed by complications. - The above results are reported in detail, compared with literature data, and discussed.

Biopsy↗
PubMed1993

[Colposcopic aspects of the cervix (cervical score CCL)].

TYPE OF STUDY: A retrospective study reviewing 481 colposcopic scores carried out on patients examined at CCL with a suspicion of dysplasia of the cervix, between January 1990 and September 1992. AIM: To evaluate the use and the reliability of a score designed to estimate the degree of severity of cases of cervical intra-epithelial neoplasia (CIN). METHOD: Each method that describes the appearances of cervical pathology has been introduced in to a computerised programme. This places the score empirically limited to each parameter according to certain specific criteria worked out at CCL. RESULTS: The correlation of the CCL cervical score has been proven to be excellent because the sensitivity of this test is 88.7% and contributes to the majority of controlled diagnoses. CONCLUSION: The principal value of a colposcopic score lies in the strictness with which the lesions are described and contributes to raising the quality of training of colposcopists and teaching this sub-specialty. Furthermore a systematic application of the analysis carried out makes it possible to take biopsies clearly directed and this is judged necessary. (CCL is the Centre of Colposcopy and Laparoscopy in the Department of Gynaecology and Obstetrics in the University of Lausanne.)

Acetates↗