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PubMed1986

Epidemic measles in Chicago in 1983. Sustained transmission in the preschool population.

We evaluated epidemiologic features of 54 patients with measles seen at Wyler Children's Hospital during a 1983 measles epidemic in Chicago. Forty-one (76%) were less than 5 years old, and 23 (43%) were less than 16 months old. We found evidence of a low rate of measles immunity in preschool-aged children of immunization age immediately before the epidemic; only 62% of 173 emergency room patients this age had antibody on enzyme-linked immunosorbent assay. These observations, together with failure of school-based control measures to significantly affect the observed course of the epidemic, indicate that the preschool population sustained the epidemic. Unimmunized preschool-aged children are important in the current epidemiology of measles, and improved immunization strategies are needed to control measles in this population in Chicago and perhaps other cities.

Antibodies, Viral↗
PubMed1977

The Chicago variant of clinical galactosemia.

A new variant of clinical galactosemia with two hitherto unidentified alleles on the transferase locus in one family is described. This new clinical variant of transferase has 25% of normal control activity in blood and in skin fibroblasts, and the patient accumulates galactose-1-phosphate in blood on an unrestricted galactose diet. Using starch gel electrophoresis on the hemolysate of the family members, a fast-moving transferase with mobility in between those of the normal control and of the Duarte variant is identified. This new allele is designated as GALTC1 (fast-moving Chicago variant). In addition, a second new allele was documented in this family by studying the instability of the transferase enzyme in hemolysates of family members at 50 degrees C for various time intervals. This new allele is designated as GALTC2 (heat-labile Chicago variant). On the basis of these studies, the transferase genotype of this patient is thought to be a double heterozygote compound, GALTC1/GALTG.

Alleles↗
PubMed1990

Warfarin resistance in a Chicago strain of rats.

A warfarin-resistant strain of rats trapped in Chicago was studied to determine the mechanism of the warfarin resistance. The Chicago-resistant rats (CR) differ from a Welsh-resistant strain (WR) which has a vitamin K epoxide reductase that is insensitive to warfarin. The epoxide and dithiol-dependent quinone reductases of the CR rats were as sensitive to warfarin as the normal enzyme. Unlike the irreversible warfarin inhibition seen in normal rats, the warfarin inhibition of the epoxide reductase from the CR strain was partially reversible in vitro. In this respect, the CR rats appeared similar to a Scottish warfarin-resistant strain. The same steady-state level of warfarin (40 ng/mg protein) in liver microsomes could be achieved in normal and CR strain rats following a few days ingestion of a diet containing 50 ppm warfarin, but clearance of warfarin (1 mg/kg) from the liver microsomes was more rapid in the CR strain than in normal rats, and the recovery of epoxide reductase activity and prothrombin levels was more rapid. The mechanism of warfarin resistance in the CR strain differed from the warfarin resistance mechanisms of both the Scottish- and Welsh-resistant rat strains. The combination of an increased rate of warfarin clearance and the partially reversible inhibition of the epoxide reductase would be sufficient to allow the rats to survive a limited exposure to warfarin.

Animals↗
PubMed1988

Indirect allosteric effects of a neutral mutation. Structure of deoxyhaemoglobin north Chicago (ProC2(36)beta----Ser).

Haemoglobin North Chicago (ProC2(36 beta----Ser) has an abnormally high oxygen affinity. A survey of other abnormal human haemoglobins with high oxygen affinity has indicated that mutations leading to a cavity in the quaternary T-structure, or to the rupture of any bond in that structure, have raised oxygen affinities, because such mutations loosen the constraints of the T-structure. They do not usually affect the oxygen affinity of the R-structure. Haemoglobin North Chicago aroused our interest because the side-chain of serine is smaller than that of proline by only one carbon atom, and it was hard to conceive how such a small gap should raise the oxygen affinity significantly. Our X-ray study shows that the mutation produces unexpectedly large indirect changes in the T-structure.

Crystallization↗
PubMed1989

Antithrombin Chicago, amino acid substitution of arginine 393 to histidine.

Antithrombin Chicago is a functionally inactive antithrombin variant whose inheritance is associated with thrombotic disease. The variant antithrombin was isolated from plasma of the propositus by chromatography on heparin-Sepharose, followed by passage through thrombin-Sepharose to remove the normal antithrombin component that is present. A pool of fragments ("CNBr pool 4") containing the reactive site region was prepared from the reduced and S-carboxymethylated variant by cleavage with cyanogen bromide followed by reverse-phase HPLC. Sequential treatment of CNBr pool 4 with trypsin and V8 protease produced peptides whose molecular masses were then determined by fast atom bombardment mass spectrometry. The variant protein digests were characterised by a reduction of a peptide of mass 1086, corresponding to the normal antithrombin sequence Ala382-Arg393. However, they contained a peptide of mass 1748, which arises when Arg393 is replaced by His in the sequence Ala382-Arg399. It is concluded that the functional and clinical abnormalities of antithrombin Chicago are all probably caused by a single amino acid substitution, Arg393 to His.

Amino Acid Sequence↗
PubMed2006

Excellent local tumor control regardless of extent of surgical resection after treatment on the Chicago Pilot II protocol for neuroblastoma.

BACKGROUND: Our aim was to investigate the impact of the extent of surgical resection on local recurrence and survival in high-risk patients treated with the Chicago Pilot II protocol. METHODS: Retrospective chart review was performed on 30 patients enrolled in the Chicago Pilot II protocol between 1995 and 2003. Variables studied were location of tumor, extent of resection, timing and location of recurrence, MYCN amplification, surgical complications, event-free survival, and overall survival (OS). Operative reports and postoperative meta-iodobenzylguanidine scans were used to assess extent of resection. Complete resection (CR) was defined as no gross residual tumor including primary and nodal disease. RESULTS: Three-year event-free survival and OS of this cohort of 30 patients was 58% and 82%, respectively. Only 1 patient developed a local recurrence, whereas metastatic recurrent disease was observed in 13 (43%) of the 30; and this subset had a significantly worse OS (23% vs 94%, P = .001). The most common relapse location was in bone. Patients with incomplete resection (IR) (11/30) and CR (19/30) had recurrence rates of 64% (7/11) and 32% (6/19, P = .12), respectively. Event-free survival was significantly better for patients with CR (68%) vs IR (27%; P = .05; odds ratio, 2.9). Overall survival rates for patients with CR vs IR were 68% vs 55%, respectively (P = .25). CONCLUSIONS: Recurrence rate was the significant determinant of survival. Patients with CR had lower recurrence rates; however, they did not have improved local control. Final outcome of patients with unfavorable neuroblastoma will be determined by metastatic recurrence, not by extent of resection.

Child↗
PubMed2000

Transformation and degradation of the disazo dye Chicago Sky Blue by a purified laccase from Pycnoporus cinnabarinus.

The degradation of the disazo dye Chicago Sky Blue 6B by a purified laccase from Pycnoporus cinnabarinus was investigated. Laccase was purified to homogeneity and characterized. The enzyme had a molecular size of 63 kDa as determined by SDS-PAGE and an isoelectric point at pH 3. Amino acid composition and N-terminal amino acid sequence was shown to be similar to other fungal laccases. The purified laccase was stable for 1 h at 60 degrees C and was irreversibly inactivated by sodium azide at 0.1 mM. Laccase was shown to initiate destruction of the chromophore of the disazo dye Chicago Sky Blue, resulting in the formation of two intermediate products with absorption intensities about one order of magnitude lower than the parent molecule. The rate at which the dye was transformed by purified laccase was shown to increase with increasing concentrations of the enzyme.

Journal Article↗
PubMed2004

"Clever Microbes": bacteriology and sanitary technology in Manchester and Chicago during the progressive age.

A neglected aspect of the history of germ theories is its use in the purification of sewage. In the 1890s, progressive reformers rapidly developed bacteriological methods of wastewater treatment. A comparison of the United Kingdom's Manchester and the United States' Chicago shows, however, that science and technology were mediated by political culture and institutions. In Manchester, a politics of deference and strong extralocal government gave the authority of scientific expertise a decisive role in policy formation. In Chicago, devolution of power to the ward bosses meant a quarter-century of defiance against the national authority and its effort to get the city to install a modern sanitation system.

Bacteriology↗
PubMed1982

Recent European immigration to the Chicago metropolitan area.

Patterns of European migration to the Chicago metropolitan area are examined to determine the urban spatial distribution of various ethnic groups. Data are from petitions of 1,185 male immigrants 18 years old and over from Greece, Italy, Poland, and Yugoslavia who applied for U.S. citizenship between June 2, 1975, and June 1, 1976. It is found that the majority of those studied chose to live within the city of Chicago. It is suggested that "residential locations of relatives, availability of low-cost housing, religious affiliations, proximity and access to employment opportunities, and avoidance of Black and Hispanic neighborhoods...were involved in the decision of where to reside." (summary in FRE, SPA)

Americas↗
PubMed2005

Systemic training for healthcare professionals: the Chicago Center For Family Health approach.

There has been increasing interest in family-centered, collaborative, biopsychosocial models of care by health and mental health professionals and consumers. This trend has led to growing demand and development of specialized training in family systems approaches to health care. This article describes the Families, Illness, and Collaborative Healthcare programs developed at the University of Chicago affiliate, the Chicago Center for Family Health. The program philosophy is guided by the following principles: a systems orientation focused on the family, a Family Systems Illness Model, a family resilience framework, a family-centered collaborative model of health care, and a social justice and advocacy orientation. Specific training components that implement these principles are described, including intensive certificate and fellowships; workshops, conferences, and institutes; and consultation and training services for community-based organizations. Discussion includes professional networking opportunities, funding challenges, and policy recommendations.

Certification↗
PubMed1989

The clinical medical humanities program at Loyola University of Chicago.

The authors emphasize that an effective medical humanities program must be based on clinically oriented training. They then describe in detail such a program at Loyola University of Chicago Medical Center; the program consists of a four-year required curriculum that is clinically reinforced by having the students accompany attending physicians on rounds and is taught by faculty representing a wide range of disciplines in medicine and other fields. The paper offers several guidelines to the person or persons who would organize and direct a clinical medical humanities program, describes obstacles that the Loyola program faced when it was getting started, presents the purpose, focus, and curricular topics of the program, and discusses its future. The authors conclude that the use of the clinically oriented approach will continue to prevail in medical humanities teaching, both at Loyola and in medical humanities programs overall. This approach challenges good teachers to make their best efforts at reconciling their own disciplines with that of medicine; in this process, a new medical humanities discipline emerges that is not so much an application of the humanities to medicine as it is an evocation of humanities themes from the clinical encounter itself.

Chicago↗
PubMed2003

Body mass index in middle age and health-related quality of life in older age: the Chicago heart association detection project in industry study.

BACKGROUND: Overweight and obesity are associated with higher morbidity and shorter life expectancy, but the effect of body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) ascertained during middle age on subsequent quality of life among older survivors is unknown. This study evaluates whether BMI in middle age is related to health-related quality of life in older age. METHODS: This prospective cohort of adults from the Chicago Heart Association Detection Project in Industry included 6766 middle-aged men and women, aged 36 to 64 years, without diabetes mellitus or myocardial infarction at baseline (November 7, 1967-January 8, 1973), who completed a 26-year follow-up questionnaire in 1996 when they were 65 years and older. Relationships of baseline BMI (categories: normal weight, overweight, and obese) to mean 26-year follow-up Health Status Questionnaire 12 scores (measuring physical, mental, and social well-being) were assessed. RESULTS: For men and women, BMI had significant inverse-graded associations with all Health Status Questionnaire 12 scores (P<.01 for trend for all). Scores (adjusted for baseline cardiovascular disease risk factors and 1996 age) were highest (best) in normal-weight individuals (BMI, 18.5-<25.0) and decreased significantly (P range,.006-<.001 for trend) with higher BMI, with worst outcomes for obese persons (BMI, >or=30.0). A higher multivariate-adjusted percentage of normal-weight persons reported excellent or very good health compared with overweight and obese persons: for women, 46.8% vs 37.9% and 24.3%; and for men, 53.8% vs 49.1% and 36.5% (P<.001 for trend). CONCLUSIONS: A higher BMI in middle age is associated with a poorer quality of life in older age. Preventive measures may lessen the burden of disease and impaired quality of life associated with excess weight.

Aged↗
PubMed1996

Growth of Chicago-area infants, 1985 through 1987. Not what the reference curves predict. Pediatric Practice Research Group.

OBJECTIVE: To determine if the National Center for Health Statistics (NCHS) growth curves (including 867 white infants, born between 1929 and 1975, in the Yellow Springs, Ohio, area) reflect contemporary infant growth in pediatric practices. DESIGN: Observational cohort study of healthy term infants. Office personnel obtained standardized measurements at health maintenance visits. SETTING: Ten pediatric community practices that were members of the Chicago, III, area Pediatric Practice Research Group (PPRG). METHODS: Measurements of 1574 PPRG infants, seen on at least 5 occasions between 2 and 54 weeks of age, generated sex-specific growth curves using a 3-parameter mathematical model fitted to the serial data for each infant. Values from the computed curves were compared with NCHS growth references at 1, 3, 6, 9, and 12 months. The birth weights of PPRG and NCHS cohorts were compared. RESULTS: Mean birth weight of PPRG infants was significantly greater than a similar NCHS measure. Compared with the NCHS reference curve, PPRG infants were heavier at 1, 3, and 6 months, longer on all comparisons, and had greater head circumferences, particularly in the early months of age. CONCLUSIONS: The NCHS growth curves do not accurately reflect infant growth in this cohort. Nationally representative data are needed to revise the NCHS growth curves.

Birth Weight↗
PubMed1980

Coping styles of Chicago adults: effectiveness.

With a sample of 2,299 Chicago adults, a quantitive exploration is made of the effectiveness of different coping styles in dealing with stressor situations and feelings of distress associated with marriage, parenting, finances, and job; psychiatric symptomatology; and feelings of low self-efficacy. The specific measure of effectiveness is the extent to which one or more coping styles predicts a given dependent variable in a multiple regression analysis. As a group. coping strategies are more predictive of the stressor situation and feelings of personal distress than of psychiatric symptomatology or feelings of low self-efficacy. Also, coping styles relate differentially among the four life areas; they are more predictive of levels of stressors in marriage and parenting than in finances or job. Some coping styles are strongly predictive of low amounts of stressors; this is particularly true of the use of strategies that invoke direct action.

Adaptation, Psychological↗
PubMed1975

Influenza type B-related encephalopathy. The 1971 outbreak of Reye syndrome in Chicago.

Between Jan 15 and March 15, 1971, forty-eight grade-school patients living in western Chicago were hospitalized with an encephalopathic illness. Fourteen of these children had illnesses compatible with Reye syndrome (encephalpathy with liver impairment). Most of the children showed evidence of central nervous system (CNS) dysfunction within ten days after onset of a febrile upper respiratory tract illness. Seizures developed in 11 of the 48 patients (including 4 of the 14 with Reye syndrome). Eight of the encephalopathic patients, including 6 of the 14 with Reye syndrome, died. Two children without Reye syndrome had abnormalities of liver enzymes coincident with cerebrospinal fluid pleocytosis. Sixteen of the 24 patients tested had titer rises in serum against influenza type B only; influenza type B was isolated from throat cultures of 2 patients. This, the seventh report of CNS complications (Reye syndrome) associated with influenza type B, suggests that surveillance for neurologic sequelae should become part of the epidemiologic evaluation of influenza epidemics.

Adolescent↗
PubMedDate not supplied

Incidence and onset features of diabetes in African-American and Latino children in Chicago, 1985-1994.

AIMS: The study aimed to describe the epidemiology of diabetes in minority children residing in Chicago, IL, USA, and to compare the demographic and clinical characteristics of those with type 1 to those with youth-onset type 2 diabetes. METHODS: Medical records were obtained on 735 insulin-treated African-American and Latino children aged 0-17 years at onset, and diagnosed between 1985 and 1994; 195 of the children were interviewed. Subjects were presumed to have type 2 diabetes if they fitted specific criteria. Univariate and multivariate analyses were conducted and Poisson regression was used to analyze time trends. RESULTS: Ten-year average annual incidence of childhood diabetes for African-Americans [15.2/10(5), 95% confidence interval (CI): 13.5, 17.0] was significantly higher than for Latinos (10.7/10(5), 95% CI: 9.1, 12.6). The average annual incidence was 10.3/10(5) population for type 1 and 3.2/10(5) for those with presumed type 2 diabetes. Most patients (99.6% of type 1, 94.1% of type 2) exhibited more than one of the classic onset symptoms of type 1 diabetes. Mean age at diagnosis was older, 13.1 versus 10.5 years, and there were more females, 62.4%, versus 49.8%, among the type 2 patients; ethnicity was not an important distinguishing factor. CONCLUSION: The risk of childhood diabetes increased among African-Americans and Latinos between 1985 and 1994, driven by an increase in children with type 2 diabetes. This is likely related both to an increase in risk factors, i.e. obesity, and to changes in diagnostic practice.

Adolescent↗
PubMed1992

Forty four years of dermatophytes in a Chicago clinic (1944-1988).

Data are presented on 39,270 cultures taken over a 44 year span (1944-1988) at the University of Chicago's Dermatology Clinic. In the mid 1940's Microsporum audouinii accounted for 60-80% of isolates. It gradually decreased over the next two decades and disappeared altogether in the 1970's. Trichophyton rubrum, rare in the 1940's accounted for over 60% of isolates in the mid-1960's only to be overtaken by T. tonsurans. This species, not isolated till the mid 1950's, became and remains the dominant dermatophyte at the present time. Both T. mentagrophytes and Epidermophyton floccosum increased in the 1970's and decreased later. Unusual circumstances resulted in clusters of T. verrucosum, T. terrestre, and T. schoenleinii isolates. Infections were associated with rural dairy workers, zoo handlers and immigrant families respectively. M. canis and M. gypseum were steady at a low rate throughout the entire period. Rare isolates included M. cookei, M. persicolor, M. racemosum, T. simii, T. soudanense, T. violaceum, and the soil keratinophile, Aphanoascus fulvescens.

Chicago↗