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PubMed2002

The Anthrax Vaccine Program: an analysis of the CDC's recommendations for vaccine use.

The anthrax vaccine was never proved to be safe and effective. It is one cause of Gulf War illnesses, and recent vaccinees report symptoms resembling Gulf War illnesses. The vaccine's production has been substandard. Without adequate evaluation, the Food and Drug Administration recently approved (retrospectively) significant changes made to the vaccine's composition since 1990. The vaccine's mandatory use for inhalation anthrax is "off-label." A skewed review of the vaccine literature by the Centers for Disease Control and Prevention (CDC) led to remunerative collaborative research with the army, involving civilian volunteers. Despite acknowledging possible fetal harm, the CDC offered the vaccine to children and pregnant women. New trends could weaken prelicensure efficacy and safety review of medical products intended for biodefense and avoid manufacturer liability for their use.

Anthrax↗
PubMed2000

Infection of B cell-deficient mice with CDC 1551, a clinical isolate of Mycobacterium tuberculosis: delay in dissemination and development of lung pathology.

Long-term survival of mice infected with Mycobacterium tuberculosis is dependent upon IFN-gamma and T cells, but events in early phases of the immune response are not well understood. In this study, we describe a role for B cells during early immune responses to infection with a clinical isolate of M. tuberculosis (CDC 1551). Following a low-dose infection with M. tuberculosis CDC 1551, similar numbers of bacteria were detected in the lungs of both B cell knockout (IgH 6-, BKO) and C57BL/6J (wild-type) mice. However, despite comparable bacterial loads in the lungs, less severe pulmonary granuloma formation and delayed dissemination of bacteria from lungs to peripheral organs were observed in BKO mice. BKO mice reconstituted with naive B cells, but not those given M. tuberculosis-specific Abs, before infection developed pulmonary granulomas and dissemination patterns similar to wild-type animals. Further analysis of lung cell populations revealed greater numbers of lymphocytes, especially CD8+ T cells, macrophages, and neutrophils in wild-type and reconstituted mice than in BKO mice. Thus, less severe lesion formation and delayed dissemination of bacteria found in BKO mice were dependent on B cells, not Abs, and were associated with altered cellular infiltrate to the lungs. These observations demonstrate an important, previously unappreciated, role for B cells during early immune responses to M. tuberculosis infections.

Aerosols↗
PubMed1997

CDC guidelines for infection precautions.

The Centers for Disease Control and Prevention (CDC) has revised its infection control recommendations for health care organizations and their staffs. Although the CDC guidelines are not home care specific, providers can use these precautions in most health care delivery sites, including in-home services.

Centers for Disease Control and Prevention, U.S.↗
PubMed1998

Proposed vaccine information materials for hepatitis B, Haemophilus influenzae type b (Hib), Varicella (chickenpox), and measles, mumps, rubella (MMR) vaccines--CDC. Notice with comment period.

Under the National Childhood Vaccine Injury Act (42 U.S.C. section 300aa-26), CDC must develop vaccine information materials that health care providers are required to give to patients/parents prior to administration of specific vaccines. CDC seeks written comment on proposed new vaccine information materials for hepatitis B, Haemophilus influenzae type b, and Varicella vaccines, and revised vaccine information materials for measles, mumps, rubella (MMR) vaccines.

Centers for Disease Control and Prevention, U.S.↗
PubMed1999

[Mycobacteria--methods to meet the CDC guidelines].

In response to the guidelines from the Centers for Disease Control and Prevention, Atlanta, U.S.A. (1994), a considerable effort has been focused on the development and application of rapid laboratory testings for Mycobacterium tuberculosis. Concerning the first goal, "acid-fast bacillus smear results should be reported within 24 hr of specimen collection", most laboratories latently have an ability to perform unless the specimens will be processed in a lump. However, the second goal, "isolation and identification of M. tuberculosis should be within 10 to 14 days", is almost impossible for most Japanese laboratories where the radiometric Bactec 460 system is not applicable. In recent years, several nonradiometric, automated or semiautomated mycobacterial culture systems are developed and applied. To date, the evaluated results indicate that the newly developed mycobacterial culture systems with Middlebrook 7H9 broth can report positive with means of 17 to 20 day incubation, 3 to 6 days behind the CDC guidelines. Finally, regarding the third goal, "susceptibility test results should be within a total of 15 to 30 days", our developed microdilution test method can report quantitative minimum inhibitory concentrations (MICs) for M. tuberculosis after 7 day incubation. Overall, our procedures are very close to the CDC guidelines, except for isolation and identification of M. tuberculosis. The remaining key to fulfil the guidelines is a rapid detection, that is, culture media which can support rapid mycobacterial growth and advanced technology to detect attenuated growth of M. tuberculosis.

Bacteriological Techniques↗
PubMed1999

Interim polio vaccine information materials. Centers for Disease Control and Prevention (CDC), Department of Health and Human Services. Notice.

The Centers for Disease Control and Prevention has modified its recommendation for use of the two polio vaccines to discourage use of oral poliovirus vaccine (OPV) for the first two doses administered, except in limited circumstances. This revised recommendation necessitates a revision of the vaccine information statement entitled, "Polio Vaccines: What You Need to Know" (dated February 6, 1997), which was developed by the CDC as required by the National Childhood Vaccine Injury Act of 1986 (NCVIA). To ensure that up-to-date information is available regarding this revised recommendation, CDC is distributing the following interim polio vaccine information statement for use pending completion of the formal revision process mandated by the NCVIA.

Centers for Disease Control and Prevention, U.S.↗
PubMed2000

Prevention works for women: women's health at the CDC.

Actively protecting America's health and safety, the Centers for Disease Control and Prevention (CDC) focuses on four priorities: 1) strengthening science for public health action, 2) collaborating with health care partners for prevention, 3) promoting healthy living at every stage of life, and 4) promoting health globally. The CDC plays a critical role in promoting the health and safety of women across the lifespan, through programs on human immunodeficiency virus infection, injury, contraceptive safety and efficacy, adolescent health, smoking, breast and cervical cancer, cardiovascular disease, and reproductive health.

Centers for Disease Control and Prevention, U.S.↗
PubMed2001

Guidelines for laboratory test result reporting of human immunodeficiency virus type 1 ribonucleic acid determination. Recommendations from a CDC working group. Centers for Disease Control.

Monitoring human immunodeficiency virus type 1 (HIV-1) ribonucleic acid levels (also known as HIV viral load) has become the standard of care for monitoring response to therapy in HIV-infected patients. In 1999, CDC published updated surveillance case definitions for HIV infection and acquired immunodeficiency syndrome (AIDS) reporting, including positive results of HIV-1 viral detection tests (CDC. Guidelines for national human immunodeficiency virus case surveillance, including monitoring for human immunodeficiency virus infection and acquired immunodeficiency syndrome. MMWR 1999;48[No. RR-131:1-28). Since 1996, an increased number of public and private laboratories have begun performing viral load tests. Results obtained with available test methods are variable, and laboratories present these results in different ways, indicating that guidelines to promote standard practice in reporting of test results are warranted. This report provides guidelines for standardized reporting of viral load test results by licensed laboratories to health-care providers and facilities for public health case reporting of HIV infection and AIDS. Recommended standards were developed through data review, input involving a working group of physicians and laboratorians experienced in viral load testing, and an assessment of laboratory practices. These guidelines were discussed, refined, and endorsed at the annual Human Retrovirus and Hepatitis C Laboratory Testing Conference, held March 6-9, 2000, in Charlotte, North Carolina, with participation of representatives from public health, hospital, independent, and blood-collection-facility laboratories. Adoption of these guidelines by all public and private laboratories that perform HIV viral load testing will improve the quality and usefulness of viral load test results for the physician ordering the test and for reporting to public health departments.

Clinical Laboratory Techniques↗
PubMed2002

2000 CDC Growth Charts for the United States: methods and development.

OBJECTIVES: This report provides detailed information on how the 2000 Centers for Disease Control and Prevention (CDC) growth charts for the United States were developed, expanding upon the report that accompanied the initial release of the charts in 2000. METHODS: The growth charts were developed with data from five national health examination surveys and limited supplemental data. Smoothed percentile curves were developed in two stages. In the first stage, selected empirical percentiles were smoothed with a variety of parametric and nonparametric procedures. In the second stage, parameters were created to obtain the final curves, additional percentiles and z-scores. The revised charts were evaluated using statistical and graphical measures. RESULTS: The 1977 National Center for Health Statistics (NCHS) growth charts were revised for infants (birth to 36 months) and older children (2 to 20 years). New body mass index-for-age (BMI-for-age) charts were created. Use of national data improved the transition from the infant charts to those for older children. The evaluation of the charts found no large or systematic differences between the smoothed percentiles and the empirical data. CONCLUSION: The 2000 CDC growth charts were developed with improved data and statistical procedures. Health care providers now have an instrument for growth screening that better represents the racial-ethnic diversity and combination of breast- and formula-feeding in the United States. It is recommended that these charts replace the 1977 NCHS charts when assessing the size and growth patterns of infants, children, and adolescents.

Adolescent↗
PubMed2001

[Is the epidemiological surveillance system of nosocomial infections recommended by the American CDC applicable in a Chilean hospital?].

BACKGROUND: The National Nosocomial Infections Surveillance System (NNIS system) is the method for surveying nosocomial infections used by the Centers for Disease Control (CDC). This strategy allows the comparison of different hospitals, using rate adjustments. In Chile, this system is not used. AIM: To report the application of this system in a tertiary reference hospital in Chile. MATERIALS AND METHODS: We performed a six months prospective cohort study. The active surveillance was carried out by using the intensive care unit and surgery components of the NNIS system. Tabulation and analysis of the data were done according to the NNIS system. In a parallel prevalence study, we determined the NNIS system sensitivity to detect nosocomial infections. RESULTS: A total of 492 patients were followed with a global nosocomial infection rate of 14%, for discharged patients. The calculated sensitivity and specificity of the system was 84.2 and 97% respectively. In the intensive care unit, 45 of 169 patients had nosocomial infections, with an adjusted rate of 2.8% for mean hospitalization time and severity of illness. In the cardiovascular and thoracic surgical units, 216 and 107 procedures were surveyed, respectively. The global rates of nosocomial infections were 7.4 and 7.5%, respectively. The adjusted rates according to risk factors were 0.9 and 2.3%, respectively. CONCLUSIONS: These data indicate that the surgical units had surgical site infections rates similar to those reported by the CDC. Nosocomial infections rates in Chile can be compared with rates observed in other countries. The epidemiological data collected can be useful to focus intervention or preventive strategies.

Centers for Disease Control and Prevention, U.S.↗
PubMed2002

[Infection prevention and safe practice (referring to CDC guideline)].

Recent nosocomial infections, such as HCV and tuberculosis, have stimulated interest in infection control practices in health care setting. Therefore, Infection Control Doctors (ICDs) have already started to make best strategies for infection prevention and safe practice. However, many obstacles lie ahead of them, with the cost as the most important. It has been believed that it takes a lot of money for the improvement of infection control. But, this aspect has been changed completely by introduction of EBM because EBM can point out and quite unnecessary practices, resulting in saving money. CDC has been published many guidelines which is evidence based. Therefore, it might be best strategy to introduce CDC guideline into the infection control in Japanese hospitals.

Centers for Disease Control and Prevention, U.S.↗
PubMed2003

The CardioOP-Data Clas (CDC). Development and application of a thesaurus for content management and multi-user teleteaching in cardiac surgery.

OBJECTIVES: Self-directed and customized medical education programs are gaining importance in health care instruction. We prototypically implemented a repository-driven online computer system (CardioOP) for teleteaching in Heart Surgery. It supports authoring and multiple re-use of multimedia data for different user groups in different instructional applications and therefore requires a process of content management. METHODS: We defined objectives for a terminological system to support semantic, cross-media type annotation and retrieval of learning objects: domain completeness, German (natural) language processing, multi-user concepts, extensibility and maintenance, content based annotation and technical implementation. Existing terminologies (ICD10, READ V3, Snomed III, UMLS 1997, MESH) have been analysed according to these objectives. RESULTS: We found that the analysed terminologies did not meet our criteria sufficiently. Therefore, we developed a domain-specific thesaurus, the CardioOP-DataClas (CDC). The application of the CDC within a database-driven authoring process using specifically developed tools is reported. CONCLUSIONS: Metadata play an important role in the effective discovery and search, access, integration and management of educational multimedia data in medicine but so far, there is no terminology to support content management for instructional multimedia. We prototypically designed and applied a thesaurus for the CardioOP educational system. Additional work is needed to evaluate the system in terms of user-friend-liness, concept coverage and information retrieval performance.

Cardiac Surgical Procedures↗
PubMedDate not supplied

Changes in public concern about transmission of AIDS from dentist to patient after CDC report.

This study was conducted to examine the impact on the public of a report from the Centers for Disease Control of the possible transmission of AIDS from a Florida dentist to his patient. Differences in the findings between two identical telephone surveys conducted approximately five months apart are reported. The second survey occurred approximately three months following the CDC report. The response rates to spring and fall 1990 surveys were 68.9 percent and 69.9 percent, respectively. Approximately 60 percent of the respondents to the fall survey reported that they had read or heard of the incident. Public concern about the transmission of AIDS in the dental office increased significantly following the CDC report. This concern was expressed in a decreased willingness to remain in the practice of dentists infected with AIDS or those who treated infected patients. In addition, respondents to the fall survey were less respectful of provider and patient confidentiality.

Acquired Immunodeficiency Syndrome↗
PubMed1964

THE CDC-CDCR DOCUMENTATION PROJECT.

A progress report on an experiment in mechanized methods for the storage and retrieval of communicable diseases information. The project, supported by National Institutes of Health grants and begun in 1958, is being conducted by the Center for Documentation and Communication Research (CDCR), School of Library Science, Western Reserve University, Cleveland, Ohio, in cooperation with the Communicable Disease Center (CDC), United States Public Health Service, Atlanta, Georgia. Initial phases have been completed. Seventy-seven questions submitted by the CDC Documentation Committee have been searched by CDCR on their GE-225 computer. For seventy-three of the seventy-seven questions, the system responded with at least one appropriate answer. The combined pertinent and peripheral responses totaled 94.7 percent. The file of abstracted literature is being increased preparatory to large-scale testing. Further investigation and evaluation are necessary before the project can be fairly appraised.

Abstracting and Indexing↗
PubMed2003

Creating public health standard vocabularies: mapping a set of CDC's pathogen codes to SNOMED concepts.

CDC and its public health partners are conducting pilot projects designed to capture data directly from healthcare providers or to exchange existing data electronically.1 The translation of proprietary standards into the accepted national standards is a key part of this effort. This study mapped a set of pathogens within CDC's hospital infection control activities to The Systematized Nomenclature of Medicine (SNOMED) concepts and investigated the differences between the two.

Bacteria↗
PubMedDate not supplied

[Effectiveness of interventions for the control and prevention of tuberculosis in health care facilities: a review of ATS,CDC, OSHA recommendations].

BACKGROUND: Health care workers (HCWs) are occupationally exposed to a multitude of biological hazards, and among these to the risk of tuberculosis (TB) infection, especially involving individuals working in specific workplace (TB and Chest divisions, Infectious Diseases wards, Microbiology laboratories) and performing thoracic endoscopy and "cough-inducing" procedures. According to national legislation (title VIII D.lgs. 626/94, 1998 Health Minister guide lines document) concerning the control and prevention of TB transmission among HCWs, health care facilities are required to (i) perform an accurate risk assessment and (ii) implement an exposure control plan and worker health surveillance program, thus involving the occupational health professionals. OBJECTIVES: The aim of this paper is to provide a general view of the epidemiological and scientific evidence related to the effectiveness of health interventions in the prevention of occupational TB infection. METHODS: Comparative evaluation and critical review of U.S. CDC (1994) guidelines, OSHA (1997) rules, and the most recent ATS and CDC (2000) "statement" documents. RESULTS: In low risk groups TCT shows decreased positive predictive value, high variability, and can be confounded by other factors (age, BCG, MNT), thus reducing its diagnostic value for latent TB infection. CONCLUSIONS: Recent recommendations on the control of TB infection in health care settings underline the need of implementing accurate risk evaluation in all hospital units, compared to the epidemiological profile in the community, and "targeted tuberculin testing" programs among high risk HCWs.

BCG Vaccine↗
PubMed2004

Field evaluation of CDC gravid trap attractants to primary West Nile virus vectors, Culex mosquitoes in New York State.

A field study was conducted to evaluate two CDC gravid trap attractants available for the West Nile virus surveillance program in New York State (NYS). According to potential attractiveness, a common lawn sod in NYS, Kentucky bluegrass (Poa pratensis) infusion and a rabbit chow infusion were compared for attractiveness to primary West Nile virus vectors, Culex mosquitoes. Attractiveness of each infusion was measured by the number of adult mosquitoes caught in CDC gravid traps and the number of egg rafts laid in ovitraps. Both gravid trap and ovitrap studies demonstrated that lawn sod infusion with a 7-day incubation period had better attractiveness to Culex restuans/Culex pipiens than rabbit chow infusion with the same incubation period. Attractiveness of lawn sod infusions was increased as they became aged within a week's period. Lawn sod infusion also attracted more Ochlerotatus japonicus, a potentially important West Nile virus vector in New York.

Animals↗
PubMed2005

CDC issues guidelines on treating OIs among adults. ART is cornerstone of treatment plan.

The CDC has confirmed that in the age of antiretroviral therapy clinicians may choose to treat some opportunistic infections (OIs) less aggressively. The CDC's recent guidelines emphasize the importance of antiretroviral therapy in reducing the incidence of OIs, particularly in individuals who have a CD4 t-cell count of less than 200 cells. But they also confirm that some OI treatment might pose more risks than benefits.

AIDS-Related Opportunistic Infections↗