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PubMed2001

Immunolocalization of cytokines and growth factors in subacromial bursa of rotator cuff tear patients.

Inflammation in the subacromial bursa causes pain in patients suffering from rotator cuff tear, with this long-lasting inflammation leading to fibrosis and thickening of the subacromial bursa. Both inflammatory cytokines and mechanical stress, and impingement in the subacromial space, might induce and worsen this inflammation. However, little is known of the mechanism of this inflammation. In this study, we used immunohistological staining to demonstrate the expression of Interleukin-1 beta (IL-1 beta), Tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), and basic fibroblast growth factor (bFGF) in subacromial bursa derived from the patients suffering from rotator cuff tear. On the other hand the expression of these inflammatory cytokines and growth factors were little detected only to a small degree in patients with anterior shoulder instability who did not have severe shoulder pain and impingement in the subacromial space. Our findings suggest that those inflammatory cytokines and growth factors may play an important role in inflammation of the subacromial bursa. Controlling the expression of these cytokines and growth factors might be important for treating patients suffering from shoulder pain due to rotator cuff tear.

Acromion↗
PubMed1991

Lymphoid follicle formation in the bursa of Fabricius of the chick embryo.

The colonisation of lymphoid stem cells and the following lymphoid follicle formation in the bursa of Fabricius of the chick embryo was studied histochemically and morphologically. Most basophilic haematopoietic stem cells first appeared in the mesenchyme of the distal bursa at 7 and 8 days. Basophilic cells were also seen in the loose connective tissue near the distal bursa, and in the vessels which were located dorsal to the distal bursa. They began to invade the epithelium at 10 and 11 days of incubation by digesting the basal laminar components which the fluorescent lectin probes stained. Haematopoietic stem cells were in close association with the extracellular matrix in the mesenchyme and contained abundant F-actin. F-actin also increased in the epithelial cells surrounding basophilic haematopoietic stem cells during lymphoid follicle formation. F-actin in migrating haematopoietic stem cells and epithelial cells might be involved in the migration of haematopoietic cells and the histogenesis of the lymphoid follicles. Granulopoiesis occurred mainly in the bursal mesenchyme, but some granulocytes were seen in the epithelium. The results support the extrinsic origin of the bursal lymphoid stem cells and their active migration towards the epithelium in the chick embryo. Cell-cell interactions and tissue interactions in the lymphoid follicle formation are also discussed.

Animals↗
PubMed1977

Cell transplantation into immunodeficient chicken embryos. Reconstituting capacity of cells from the yolk sac at different stages of development and from the liver, thymus, bursa of Fabricius, spleen and bone marrow of 15-day embryos.

Cyclophosphamide-treated 18-day-old chicken embryos were transplanted with histocompatible cells from the yolk sac at different stages of development and from the liver, thymus, bursa of Fabricius, spleen and bone marrow of 15-day-old-embryos. At the age of 36 days, the cell recipients were studied to determine the reconstitution capacity of the transplanted cells. The parameters used include the survival pattern, gain of body weight, antibody-forming capacity, response of peripheral blood lymphocytes to Con A, weight and microscopic morphology of the bursa of Fabricius, and weight of spleen and thymus. By all the criteria employed, only bursa cells were capable of a functional and morphological reconstitution of the recipient's humoral immune system. These data indicate that the role of the yolk sac as the first generator of prebursal stem cells remains questionable. In addition, these findings confirm the previous observations that, as a differentiation site of the B-cell lineage, the bursa of Fabricius precedes the bone marrow during ontogenetic development.

Animals↗
PubMed1989

Development of the peripheral immune function in the chicken. A study on the bursa of Fabricius isolated from the rest of the gut-associated lymphoid tissue (GALT).

The bursa of Fabricius was surgically separated from the rest of the gut-associated lymphoid tissue (GALT). The antigens, sheep red blood cells (SRBC) and killed Brucella abortus organisms, were introduced into the bursal lumen, into the gut only, or allowed to get in contact with both (controls). The antibody titres in serum, the development of the bursal weight and the bursal histology were studied at various ages. The control birds responded vigorously to both antigens at between 2 and 8 weeks of age. At that age, the isolated bursa was capable of producing full anti-Brucella response, but not the anti-SRBC response, suggesting that SRBC need collaboration between both bursal and intestinal T and B cells. After 8 weeks, the cells in the gut alone were as potent as those in the gut and the bursa together at producing antibodies to SRBC. The bursal weight was significantly higher in the per bursam immunized chickens, indicating that continuous presence of antigens in the bursa may postpone its involution.

Age Factors↗
PubMed1988

[Bursa iliopectinea--size and morphology].

The size of the iliopsoas bursa is usually larger than its size described in textbooks of anatomy. Proximally the synovial bursa lies on the pectineal eminence of the superior pubic ramus, passes across the front of the capsule of the hip joint and extends distally downwards almost as far as to the lesser trochanter. Only the tendon of the psoas major muscle is normally an immediate relation to the bursa. In 13% of all cases the iliopsoas bursa is partly separated by a septum into 2 cavities. Here the tendon of the psoas major muscle passes over the medial chamber and the tendon of the iliac muscle runs over the lateral chamber. With regard to modern diagnostic techniques (computer tomography, magnetic resonance-tomography) the results are significant for the differential diagnosis of inflammatory processes in hip joints.

Aged↗
PubMed1986

Effects of photoperiods on the weights of bursa of Fabricius and thymus in Japanese quail.

Effects of photoperiods on the growth of the bursa of Fabricius and the thymus were investigated in male (1-8 weeks after hatching) and female (5-7 weeks after hatching) Japanese quail. In males from hatching to 4 weeks of age, the bursal growth was not affected by photoperiod. However, the growth pattern was different between long and short days after 4 weeks of age, i.e., the bursal weight under long days (LD 16:8) increased rapidly until 6 weeks of age and regressed thereafter, whereas it continued to increase under short days (LD 8:16), keeping a constant ratio to body weight. The growth of the thymus showed a similar pattern to that of the bursa of Fabricius. The age for the thymus to reach the maximum weight under LD 16:8 was almost the same as that for the bursa. In LD 8:16, thymus weight increased until 6 weeks and thereafter remained constant. In females, bursa of Fabricius and thymus weights decreased from 6 to 7 weeks under LD 16:8, which was coincided well with the rapid oviduct growth, whereas the organ weights increased under short days. Thus, it was clearly shown that the growth pattern of lymphoid organs is affected by photoperiods in both male and female Japanese quail.

Animals↗
PubMed1979

Distribution and role of lymph vessels of the bursa Fabricii.

The fine distribution of lymph vessels in the bursa of Fabricius and the efferent lymph vessels coming from the bursa were demonstrated. The lymph vessels never entered lymphoid follicles, whereas the blood vessels pierced the cortex of lymphoid follicles and formed a network at the boundary between the cortex and medulla of lymphoid follicles. The lymph vessels commenced in the immediate exterior of lymphoid follicles. A large number of lymphoid cells were found in the lumen of the lymph vessels. Migration of lymphoid cells from the cortex of lymphoid follicles to the lymph vessels was also observed. Therefore, it was assumed that the lymph vessels of the bursa are important in the transport of lymphoid cells from the bursa to the blood stream.

Animals↗
PubMed1980

An area of T cell localization in the cloacal bursa of White Leghorn chickens.

Within the cloacal bursa (bursa of Fabricius), there is a diffusely infiltrated area (DIA) of lymphoid cells just dorsal to the bursal duct opening. Because this region displayed certain histologic characteristics of thymus-dependent areas found in mammals, such as high endothelial venules, heavy reticular fiber components, and epithelium infiltrated with lymphocytes, experiments were conducted to determine whether thymus-derived cells (T cells) were present. Two independent methods substantiated the presence of T cells in the DIA. After the acid alpha-naphthyl acetate staining technique, the characteristic T cell focal esterase activity could be demonstrated in significant numbers of cells found in the DIA. Also autologous radioactively labeled thymocytes could be identified in the DIA by autoradiography a few hours after IV injection. This establishment of a definite T cell area within the bursa gives additional credence to the contention that the bursa functions as a secondary lymphatic organ.

Animals↗
PubMed1982

A comparative study of age involution of the bursa of Fabricius an thymus in birds.

The differential growth patterns of the bursa of Fabricius and thymus of Comet strain chicks were examined up to 60 days of age. It was found that the bursa increased in size, in relation to body weight, during the first 3 wk of life but thereafter underwent involution. The thymic tissue increased in weight throughout the period of investigation, from 3 to 58 days of age; when this total weight was related to the number of thymus glands, it was found that during the first days of life, thymus tissue was increased by the growth of pre-existing thymic glands but that this was followed by a phase when new thymus glands appeared with no increase in the size of the largest glands. Although the growth and involution patterns of the thymus and bursa differed it was found that, for each age group, a linear relationship existed between the bursa and thymus, suggesting that there may be a common control of development in the two organs.

Aging↗
PubMedDate not supplied

Particles resembling circovirus in the bursa of Fabricius of pigeons.

Histological examination of the bursae from 12 pigeons under 4 months old revealed basophilic globular inclusion bodies, 5 to 25 microns in diameter, in the cytoplasm and the nuclei of the various bursal follicular cells. Electron microscopy of these inclusions revealed large electron-dense areas containing non-enveloped icosahedral viral particles, 14-19 nm in diameter, either loosely arranged or in paracrystalline array. Similar basophilic globular inclusion bodies were seen in the spleen and cecal tonsils of a few pigeons and in the duodenum of one pigeon. There were various degrees of lymphoid depletion in the bursa, spleen, and bone marrow. The morphology of the inclusions in the bursa and size of the viral particles are most consistent with circovirus. Preliminary studies on the bursae of two pigeons were negative for psittacine beak and feather disease (PBFD) viral antigen and nucleic acid by immunoperoxidase staining, DNA in situ hybridization, and polymerase chain reaction techniques, suggesting that this virus differs from PBFD virus. Most of the pigeons had concurrent infections such as paramyxovirus-1, salmonellosis, herpesvirus, and hepatic and cerebral trichomoniasis associated with adenovirus.

Animals↗
PubMedDate not supplied

Appearance of T cells in the bursa of Fabricius and cecal tonsils during the acute phase of infectious bursal disease virus infection in chickens.

Groups of 3-wk-old specific-pathogen-free chickens were inoculated intraocularly with two virulent and one vaccine strain of infectious bursal disease virus (IBDV). During the acute phase of infection, the bursa of Fabricius and cecal tonsil were examined by immunohistochemistry for IBDV antigen and T cell. With all three viruses examined, the infection resulted in the appearance of viral antigen in the bursa accompanied by the presence of CD3+ cells. The CD3+ cells were predominantly TCR2+ and appeared at the site where viral antigens were present. The CD3+ cells continued to persist in the bursa after most of the IgM+ cells and IBDV antigen-positive cells had disappeared. Similar appearance of CD3+ cells was noted following viral antigen accumulation in the germinal centers of cecal tonsils in virulent IBDV-infected chickens. These results demonstrated that infection with IBDV resulted in extensive viral replication in the bursa and the cecal tonsils with an associated accumulation of T cells. The role these T cells may play in the pathogenesis of IBDV infection remains to be established.

Animals↗
PubMed2001

Negative test for cloacal drinking in a semi-aquatic turtle (Trachemys scripta), with comments on the functions of cloacal bursae.

Many aquatic turtles possess paired evaginations of the cloaca called cloacal bursae. Despite more than two centuries of study, little consensus exists as to the function(s) of these organs. We tested a recent suggestion that bursae could function in water uptake ("cloacal drinking"). Turtles (Trachemys scripta) were dehydrated (68-86% of maximum body mass) and given the opportunity to drink orally or cloacally. Dehydration caused increases in hematocrit and osmolality of extracellular fluid (ECF), but only after loss of 10-12% of maximum body mass, suggesting that turtles osmoregulated by reabsorbing water from the urinary bladder. Turtles drank eagerly when they could submerge their heads, and drinking was accompanied by an increase in body mass and a decrease in ECF osmolality. However, dehydrated turtles with tail and anus submerged showed no changes in mass or osmolality, suggesting that water absorption is not a significant function of the cloacal bursae in this species. Evidence for other putative functions is reviewed, leading to a pluralistic view: in cryptodires, bursae apparently function primarily in buoyancy control and secondarily in ion transport and nesting, but several pleurodires have been shown recently to use them in aquatic respiration.

Absorption↗
PubMed2006

PCR-based detection of Theileria ovis in Rhipicephalus bursa adult ticks.

Tick-borne diseases in ruminants are common in tropical and subtropical regions and lead to meat and milk production losses. In this study, polymerase chain reaction (PCR) was used to assess the presence of Theileria ovis in Rhipicephalus bursa ticks. We have demonstrated that the PCR enabled detection of T. ovis in field isolates of R. bursa collected from naturally infested sheep and goats in eastern Turkey. The sampling was done in spring season (between May and June 2004). A total of 420 R. bursa were collected and randomly selected 192 number of them (97 female and 95 male) were dissected. Primers specific for 520 bp fragments small subunit ribosomal RNA (ssu rRNA) gene of T. ovis amplified products from 37 of the 192 (19.27%) samples. The parasite was detected in 17 (17.52%) female and in 20 (21.05%) male ticks. Two T. ovis amplicons from the tick samples were purified and sequenced. The resulting sequences were identical to the nucleotide sequence of the Turkish sheep strain of T. ovis. These results showed that R. bursa might play an important role in the field as a natural vector of T. ovis.

Animals↗
PubMed1977

The cultivation of the rumen ciliate Entodinium bursa in the presence of Entodinium caudatum.

The rumen ciliate protozoon Entodinium bursa has been grown in vitro in the presence of bacteria and Entodinium caudatum for over a year at population densities of 100 to 200 ml-1. The medium contained potassium phosphate, prepared fresh rumen fluid, cysteine, wholemeal flour (or rice starch), dried grass and a culture of the spineless form of Entodinium caudatum. Entodinium bursa has an obligate requirement for this protozoon and died within 48 h in its absence. During growth from a 2% inoculum, the mean generation time of E. bursa was 6 h. Entodinium bursa engulfed 1-5 to 2-5 E. caudatum organisms h-1, and when E. caudatum was in excess it developed caudal spines for the first time in 17 years; these spined forms were engulfed much less readily than the spineless organisms.

Animals↗
PubMed1984

The uptake and utilization of Entodinium caudatum, bacteria, free amino acids and glucose by the rumen ciliate Entodinium bursa.

Washed suspensions of Entodinium bursa were incubated anaerobically with Entodinium caudatum, ten species of bacteria and a yeast. The rate of uptake and digestion of these micro-organisms was investigated. Protozoa grown in vivo did not engulf Proteus mirabilis or Klebsiella aerogenes but rapidly took up Bacillus megaterium. Selenomonas ruminantium, Torulopsis glabrata and Streptococcus bovis, although only the last was digested with release of soluble material into the medium. Protozoa grown in vitro engulfed each of the bacteria tested, taking up Megasphaera elsdenii and Proteus mirabilis most rapidly. Individual bacterial species and mixed rumen bacteria were engulfed more rapidly (up to 20 times) by protozoa grown in vivo than those grown in vitro, although the latter digested over 80% of the B. megaterium, Escherichia coli and P. mirabilis taken up. Labelled Ent. caudatum was extensively digested after engulfment by Ent. bursa. Some of the digestion products were released into the medium but individual amino acids were transferred as such from Ent. caudatum protein to Ent. bursa protein. Engulfed bacteria and polysaccharide granules were transferred intact from one protozoon to the other. Free amino acids were also taken up intact from the medium into protozoal protein but there was little biosynthesis of amino acids from glucose. When available for engulfment Ent. caudatum was quantitatively a much more valuable source of amino acids for protein synthesis by Ent. bursa than free amino acids or bacteria.

Amino Acids↗
PubMedDate not supplied

Intra-articular anesthesia of the distal interphalangeal joint alleviates lameness associated with the navicular bursa in horses.

OBJECTIVE: To determine if intra-articular anesthesia of the distal interphalangeal joint could alleviate lameness associated with the navicular bursa in horses. STUDY DESIGN: Experimental investigation. ANIMALS: Six clinically normal horses. METHODS: Lameness was induced in each horse by injecting either the left or right front navicular bursa with 5 mg of amphotericin-B. Forty-eight hours later each horse was videotaped walking and trotting before, and 5, 30, and 60 minutes after injecting the distal interphalangeal joint of the treated limb with 5 mL of 2% mepivacaine hydrochloride. All video recordings were then rerecorded onto master tapes in a random sequence. Four clinicians, unaware of the animal identity related to observation time or limb treated, independently viewed these tapes and graded the lamenesses. RESULTS: There was a significant reduction in lameness 5 and 30 minutes after anesthetic was injected into the distal interphalangeal joint. Lameness scores 60 minutes after anesthetic administration were not significantly different than baseline values. Gross pathological examination confirmed marked inflammation of the treated navicular bursae and normal appearance of the distal interphalangeal joints. CONCLUSIONS: Intra-articular anesthesia of the distal interphalangeal joint can alleviate lameness associated with the navicular bursa. CLINICAL RELEVANCE: Intra-articular anesthesia of the distal interphalangeal joint is not specific only for lameness originating in the distal interphalangeal joint.

Amphotericin B↗
PubMed1999

Lameness associated with the bicipital bursa in an Arab stallion.

Severe, chronic lameness in the left forelimb of a five-year-old Arab stallion was localised to the bicipital bursa by local anaesthesia and gamma scintigraphy. Radiographic and ultrasonographic examinations of the proximal humeral tubercles and bicipital bursa revealed new bone production in the region of the intertubercular grooves and irregularities in the density of the soft tissues of the bicipital tendon and bursa. An endoscopic examination of the bicipital bursa with a standard arthroscope under general anaesthesia was a useful diagnostic procedure. The stallion was euthanased, and marked fibrocartilage fibrillation and formation of adhesions were found postmortem, confirming a diagnosis of chronic fibrinous bursitis.

Animals↗
PubMed1978

Gastrocnemio-semimembranosus bursa and its relation to the knee joint. IV. Clinical considerations.

The frequency of communication between the gastrocnemio-semimembranosus bursa and the knee joint was investigated in a clinical material and in autopsy cases. The frequency was higher in the older age groups. No increase in this frequency or in the size of the bursa was found in patients with knee joint lesions at arthrography. By cineradiography, and in the majority of cases by conventional arthrography alone, a good idea of the flow between the joint and the bursa was obtained. A valvular mechanism between the joint and bursa was demonstrated in 5 cases.

Adolescent↗