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[Disruption and recovery of grammatical speech in patients with acoustic-mnestic aphasia].

The clinical picture of acustico-mnestical aphasia, besides defects of understanding, naming and reiteration is characterized by disorders of a grammatical shaping of statements as well. Such disorders as yet have not been specially studied. The conducted study explored disorders and rehabilitation of speech grammar in 10 patients with acustico-mnestical aphasia with the aid of a neuro-linguistical analysis of spontaneous speech in patients and some special tests. The study made it possible to eliminate general types of agrammatism in different forms of aphasia and disorders, specific of acustico-mnestical aphasia. The suggested methods appeared to be adequate for a rehabilitation of speech grammar in this group of patients. Besides rehabilitative training may be used as a supplementary method for studying the character and structure of agrammatism in acustico-mnestical aphasia. The achieved results may be used for the diagnostics and rehabilitation of speech in this form of aphasia.

Adult↗

[A case of conduction aphasia due to small infarction in the left parietal lobe].

This is a report on the patient with conduction aphAsia due to small infarction in the left parietal lobe. The patient is a right-handed man aged 74, who developed a speech disorder and mild paralysis of the right hand on November 13. 1996. A CT scan showed a small low-density in the supramarginal gyrus of the left parietal lobe. Standard Language Test of aphasia (SLTA) conducted at five days after admission to the hospital showed preserved auditory comprehension and phonemic para-aphasia symptoms with respect to volitional speech, naming, reading aloud and repetition. Frequent self-correction was also observed while repetition was not remarkably impaired. A test at three months after the onset revealed generally fluent speech, while there still remained occasional phonemic para-aphasia and self-correction for the speech disruption. Three years and four months later, most of the aphasic syndromes disappeared, although the patient claimed he still had difficulty in speaking. This case suggests that conduction aphasia can be caused by a lesion, though small, located in arcuate fibers of the cerebrum. The characteristics are phonemic para-aphasia with respect to general speech functions as well as self-correction toward target words. The indicated that lesions in the pathway connecting Broca's area and Wernicke's area causes difficulties in selecting accurate phonemes due to a malfunctioning interface between the two areas.

Aged↗

[Disability and rehabilitation outcome in hemiplegia with global aphasia and neglect].

PURPOSE: Global aphasia and neglect are considered to be the neuropsychological disorders mostly affecting the hemiplegia outcome. The aim of this study is to examine which of the two disorders is making worse the recovery from hemiplegia. METHODS: The study was conduced on 45 patients suffering from hemiplegia: 15 subject with global aphasia, 15 with neglect and 15 without neuropsychological disorders (control group). All patients were subject to rehabilitation treatment. Before and after rehabilitation, the assessment of patients was made using neuropsychological tests, Fugl-Meyer scale and Functional Independence Measure (FIM). At admission, all patients were not self-sufficient. RESULTS: At the end of the rehabilitation period the recovery of motor function was poor in both groups. The damage on limbs motion was severe in 93.4% and marked in 6.6% of both patients with global aphasia and neglect. At discharge, the FIM motor score of patients with global aphasia (44.6 +/- 13) was higher than in those with neglect (37.2 +/- 10) and was not statistically different from control group (51.2 +/- 18) (p = 0.493). The FIM motor score of patients with neglect was significantly lower than control group (p = 0.036). In patients with global aphasia effectiveness was 35.5% and efficiency 0.40 while in patients with neglect effectiveness was 18% and efficiency 0.22. The final disability was lower in patients subject to global aphasia than neglect. CONCLUSIONS: The study showed that neglect limits the recovery from stroke more than global aphasia.e.

Activities of Daily Living↗

[A case of cerebral thrombosis presenting global aphasia without hemiparesis].

We reported a 62-year-old male with cerebral thrombosis presenting global aphasia without hemiparesis. The patient had an episode of aphasia 15 years ago, but recovered within 6 months. This time he had transient right sided mild hemiparesis, then he became aphasia next morning. When we examined at day 10 and day 15, his consciousness was clear, nothing he could speech, he could not understand or repeat. We diagnosed him global aphasia, but he had no hemiparesis except for right facial mild paresis and was able to walk. CT scan showed low density area in left and right posterior, left anterior watershed and left terminal zone. Cerebral angiography disclosed thrombotic occlusion of main trunk of left middle cerebral artery, and ambient segment of right posterior cerebral artery. Global aphasia without hemiparesis has been said a sign of embolic encephalopathy. This case was considered a very rare case, because he revealed global aphasia without hemiparesis by thrombotic occlusion.

Aphasia↗

[Two cases of primary progressive non-fluent aphasia].

Two patients were described with a five to seven-year history of primary progressive non-fluent aphasia. One patient developed atypical trascortical motor aphasia with marked anarthria, which has led to mutism. Magnetic resonance (MR) imaging showed lobar atrophy of the frontal lobe accentuated in the bilateral superior frontal gyri, the left middle frontal gyrus, the left anterior cingulate gyrus and the left operculum with some extension into the left temporal lobe. Single photon emission computed tomography (SPECT) scans demonstrated a decrease of regional cerebral blood flow (rCBF) in the atrophic site. The patient was clinically and neuroradiologically diagnosed as having Pick's disease. Another patient presented with atypical Broca's aphasia, which has worsened with slowly progressive right hemiparesis. Mitigated, sometimes complete, echolalia was also observed. MR imaging and SPECT scans showed mild atrophy and a decrease of rCBF in the left perisylvian region involving the frontal operculum, while a positron emission tomographic study disclosed diffuse hypometabolism in the left hemisphere. We pointed out that the features of primary progressive aphasia were frequently atypical in the light of classical classification of aphasia and that non-fluent aphasia might be observed even in the early stage of cortical degenerative processes.

Aphasia, Broca↗

[The effect of aphasia and organic brain damage on the variability of the results of "Token" test].

The aphasia and psychoorganic syndrome variables were taken into consideration when analysing the Token test results: 78 patients with aphasia and 150 patients with organic brain damage without aphasia were investigated. The aphasic group were subdivided into 6 categories according to language communication abilities. The patients group with brain damage without aphasia were subdivided into 4 categories according to the stage of psychoorganic syndrome. On the basis of mathematical analysis we consider that aphasia was responsible for about 65% of variability results in the Token test, psychoorganic syndrome-for 10%. The rest 25% was not connected with these two variabilities, and we could not find any explanation for this. The results mentioned above show the high specificity of the Token test for aphasia.

Adolescent↗

[Language and aphasias].

INTRODUCTION AND OBJECTIVE: Approximately 400,000 years ago men started to use language. Initially it was probably poor with few phonemes. With social evolution it became more complex, with the appearance of new phonemes and a more complete grammatical structure. The current concept of the processing of language dates, with little change, from the nineteenth century. DEVELOPMENT: With the birth of phrenology language began to be studied. This lead to the hypothesis of Wernicke, with two main areas joined by the fasciculo arcuato, which is still held to be valid with modifications by Gerchwind and Damasio, amongst others. Important advances in the study of language are due to Chomsky and his transformational grammar. This supports the universal structure of language, since one learns it following genetically determined laws. Language has three main aspects: creativity which makes both the transmitter and the receiver active participants in communication, the form from which words are constructed and the content of the message. Aphasia is an alteration in the comprehension and understanding of language, which may be the clinical expression of many different aetiologies. They help us to localize the lesion topographically. They are divided depending on the clinical signs, into motor or Broca's aphasia, in which understanding is conserved but the patient uses a language with poor grammatical structure, although the semantic content is acceptable: sensitive or Wernicke's aphasia, with inability to understand and language which is fluid but unintelligible; conduction aphasia due to limitation in the transmission of impulses from Wernicke's area to that of Broca, with acceptable understanding and fluid language and the trans-cortical aphasias where the main characteristic is indemnity of the capacity of repetition. CONCLUSIONS: The aphasias, as the expression of an alteration of language are an important support in the topographical localization of lesions, even before these can be shown on computerized tomography.

Agraphia↗

[Language rehabilitative training for postoperative aphasia in neurosurgery].

Rehabilitation nursing focus on assisting patients to reconstruct their health. We trained 21 cases of aphasia after operation with different types of early comprehensive speech reconstruction exercises, including hearing, speaking, reading and writing. We achieved expected results. Anomia aphasia has the best outcome, next is motor and sensory aphasia, and combined aphasia is less effective. In addition, patients with aphasia before surgery got slightly better rehabilitation than those whose aphasia was resulted from surgery.

Aphasia↗

[Elementary logic and semantic fields in aphasia].

Modern linguistics, like genetic psychology, postulate a non-linguistic basis for the structurisation of the semantic fields. If such is the case, it should be possible to observe in aphasia, where semantic deficiency predominates, a related disturbance in the semantic fields and logic. Paraxodically, such disturbances have been observed both in Broca's aphasia and in the predominantly semantic aphasia of Wernicke. A qualitative analysis shows that quantitatively identical results in the semantic aphasias of Broca and Wernicke are the result of phenomenological convergence. The related disturbance in the semantic fields and logic appears characteristic of the semantic deficiency which, in aphasic semiology, is marked by the substitution of one word for another. These finding support the theory of the relative autonomy of phonemic and semantic disorders in Wernicke's aphasia. They confirm the linguistic and genetic theory that the structure of vocabulatory is based on extralinguistic factors. They do not however provide an explantation for semantic disorders in aphasia. Further research is required to discover on what functional system articulation of the symbolic function and general operative capacity is based.

Adolescent↗

Subcortical crossed aphasia.

A 55 year-old, right-handed, hypertensive woman with global aphasia, due to a spontaneous hemorrhage in the right putamen extending to the periventricular white matter was examined thirteen days after the acute onset of stroke. She had left hemiplegia and inability to speak. She displayed no spontaneous speech output and was capable only of occasional undifferentiated grunts in conversation. Other language modalities such as auditory and reading comprehension, naming, repetition and writing were severely impaired. Her aphasia was classified as global aphasia. Forty-five days after the onset of stroke, rapid recovery from the aphasia with mild deficits in speaking, naming, and repetition was detected. This case is a good example of crossed aphasia, favouring the importance of deep structures of the right hemisphere in this type of aphasia. Rapid recovery is an important feature.

Aphasia↗

Acute computerized tomographic scans: their value in the localization of lesions and as prognostic indicators in aphasia.

Twenty three patients with past or present evidence of aphasia following either stroke (n = 19) or head trauma (n = 4) were given the Boston Diagnostic Aphasia Examination in order to classify their aphasia type and determine their language deficit at least three months postonset of their neurological disorder. The location and extent of brain lesions identified from computerized tomographic (C.T.) scans taken in the acute stage and, wherever possible, in the chronic stage (n = 7) were correlated with the type of aphasia. Lesions associated with global, Wernicke's, Broca's, conduction, and anomic aphasia are described and discussed in relation to the findings of previously reported clinico-C.T. scan correlation studies. The value of the acute stage C.T. scan as a predictor of long-term language deficits is discussed.

Adult↗

The occurrence of paraphasias in the spontaneous speech of children with an acquired aphasia.

Two children with an acquired aphasia were observed during the recovery process. In the spontaneous speech, paraphasias belonging to different categories, such as neologisms, verbal paraphasias, and literal paraphasias, were found. Especially with regard to neologisms the time of investigation was very important. In addition, one child with a phonemic jargon aphasia and one child with a fluent aphasia and empty speech were observed. These observations implicate a modification of the current clinical picture of childhood aphasia. Some aspects are discussed in relation to adult aphasia.

Aphasia↗

[Current status of aphasia therapy].

Aphasia therapy in adults has been established to a larger extent relatively lately in the history of aphasiology, i.e. after its social medical importance had been realized and one of the cardinal problems of neurology solved more satisfactorily--lesion localization by imaging techniques. In order to evaluate the efficiency of aphasia therapy--which is still not quite uncontradicted--it was necessary to acquire sufficient knowledge of the spontaneous recovery process. It takes place--e.g. after stroke--mainly during the first 3 months, coming, as a rule, to a halt during the first year. Longer recovery periods, however, have been described. Next to etiology neurological status, overall health condition, type and severity of aphasia, and time delay between onset of the disease and start of therapy have been ascertained, whereas age and handedness seem to be of minor relevance. If syndrome change occurs the boundary between Broca's and Wernicke's aphasia is not surpassed; this taken apart almost any change from a more severe to a milder form of aphasia is possible. To isolate the therapeutic effect from spontaneous recovery in larger groups is difficult. There are, however, more recent investigations which suggest, that a correctly indicated therapy, which is sufficiently intensive and lasts long enough, will be effective. One of the corner-stones of any therapeutic effort ist adequate stimulation, oriented toward the patients needs and his aphasic syndrome, and taking into account the systemic nature of language and its most important linguistic structural components. Furthermore, a phase-specific and interdisciplinary approach and integration of closely related persons play an important role. We divide the numerous therapeutic techniques into 3 groups: direct or stimulation approach, indirect or circumventory approach, compensatory or alternative strategies approach. Representatives of all 3 groups are presented briefly, e.g. auditory stimulation, divergent semantic intervention, promoting aphasics communicative effectiveness, language enrichment therapy, programmed instruction; then the deblocking method, melodic intonation therapy, imagery, a sample of linguistically oriented methods for the reeducation of syntax, semantics, and phonemics along with special methods for the treatment of alexia and agraphia; finally compensatory techniques like visual communication, visual action therapy, and bliss symbolics. Some particular problems encountered in working with aphasics are addressed. A point is made about the feasibility and profit of lay therapy.(ABSTRACT TRUNCATED AT 400 WORDS)

Agraphia↗

Influence of age, sex, literacy and pathologic lesion on incidence, severity and type of aphasia.

The influence of sex, age, educational level and pathologic lesion on incidence, severity and clinical form of aphasia was investigated in 390 right-handed, left brain-damaged patients. Sex and educational level were not related to any parameter. Etiology of lesion and age were related to both incidence and type of aphasia. Incidence of aphasia increased with age and was higher in patients with cerebrovascular accidents than in subjects with other types of brain lesions. Non-fluent forms of aphasia were more frequent in young patients suffering from acute cerebrovascular accidents, whereas anomia prevailed in neoplastic subjects and Wernicke's aphasia increased regularly in frequency with age. Some tentative explanations of these findings are discussed.

Adult↗

Nonfluent progressive aphasia and semantic dementia: a comparative neuropsychological study.

Two patients with nonfluent progressive aphasia, who have been studied longitudinally, are contrasted with a group of 5 patients with fluent progressive aphasia or semantic dementia. The most prominent feature of the nonfluent syndrome is the severe distortion of speech output with phonological errors and agrammatic sentence structure. This contrasts with the fluent, well articulated and syntactically correct, but empty, anomic speech found in semantic dementia. Performance on tests of comprehension separates the patient groups: The nonfluent patients show normal single-word comprehension, but marked impairment on tests of syntactic comprehension, while those with semantic dementia demonstrate the opposite pattern. Category fluency is severely defective in semantic dementia, but initial letter-based fluency is more impaired in the nonfluent syndrome. Performance on nonverbally mediated tests of semantic knowledge is impaired in semantic dementia only. The 2 forms of progressive aphasia have in common the sparing of perceptual and visuospatial skills, nonverbal problem solving abilities, and day-to-day (episodic) memory. Neuroradiological investigations have shown marked selective and striking inferolateral left temporal lobe atrophy in all 5 patients with semantic dementia. The changes in nonfluent progressive aphasia appear to be less focal and involve left perisylvian structures more diffusely. These 2 forms of progressive aphasia are, we argue, distinct in their manifestations.

Aged↗

Empty speech in Alzheimer's disease and fluent aphasia.

Fourteen measures of empty speech during a picture description task were examined in four subject groups--patients with Alzheimer's dementia, Wernicke's aphasias, anomic aphasias, and normal controls--to discover if these groups could be distinguished on the basis of their discourse. Patients with Alzheimer's dementia were distinguished from patients with Wernicke's aphasia by producing more empty phrases and conjunctions, whereas patients with Wernicke's aphasia produced more neologisms, and verbal and literal paraphasias. The demented patients shared many empty speech characteristics with patients with anomic aphasia. Naming deficits, as measured by confrontation naming tasks, did not correlate with empty discourse production. Our findings may be useful clinically for distinguishing these different patient groups.

Adult↗

Left precentral gyrus and Broca's aphasia: a clinicopathologic study.

We describe an autopsied case in which a circumscribed lesion involving the left precentral gyrus caused mild but lasting Broca's aphasia. The patient developed nonfluent speech and writing disturbances (consistent with mild Broca's aphasia) following malignant lymphoma of the brain. After subtotal resection of the tumor and whole brain irradiation, his language disturbances continued without remarkable change for 3 years until his death. A neuropathologic study indicated that the lesion responsible for the patient's aphasia was restricted to the lower one-third of the precentral gyrus in the left hemisphere. As for the relationship between the left precentral gyrus and Broca's aphasia and its allied syndrome (ie, aphemia), we concluded that in Broca's aphasia the lower part of the precentral gyrus plays a more important role than previously assumed.

Aphasia↗

[A case of thalamic germinoma with crossed aphasia in a dextral (author's transl)].

We present a rare case of thalamic germinoma with crossed aphasia in a dextral. A patient, 17-year-old righat-handed male, was admitted to Nippon Medical School Hospital with chief complaints of headache, abnormality of visual field and speech disturbance. There were pigmentations on the back of hand, foot and the perineum. Neurological examination revealed left homonymous hemianopsia, right slight degree of ptosis, left facial palsy, a mild paresis of the left upper extremity and motor aphasia. Right carotid angiography showed marked unrolling and midline shift of right anterior cerebral artery. CT scan revealed ring-like high density area in the right thalamic region, which was enhanced after constant infusion. Brain scintigraphy also showed an abnormal accumulation at the same site. The hen-egg sized tumor of 40 g. weight was almost totally removed by the right fronto-parietal craniotomy. The tumor was characterized histologically by the so-called two cell pattern with teratomatous components. As postoperative treatment local injection of adriamycine, irradiation and immunotherapy with picibanil were performed, and then left hemiparesis was markedly improved without sign of recurrence. Language evaluation was performed after operation. There were dysarthria, remarkable word amnesia, paraphasia and perseveration. Repetition was also impaired. His speech function was concluded to be a mixed type aphasia mainly composed of Broca's aphasia. The speech function of thalamus and crossed aphasia with dextrales were discussed.

Adolescent↗