TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo.

T Debeir; H U Saragovi; A C Cuello

doi:10.1016/s0928-4257(98)80011-9

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TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo.

T Debeir·H U Saragovi·A C Cuello

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Abstract

Cholinergic neurons are known to respond in vivo to the administration of nerve growth factor (NGF) by a prominent and selective increase of choline acetyl transferase activity and by cholinergic synaptogenesis in the rat brain. By using a synthetic TrkA antagonist we demonstrated that endogenously produced NGF is involved in the continual re-modeling of cholinergic neuronal connections during adulthood, acting through TrkA receptors.

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Acetylcholine Animals Cells, Cultured Cerebral Cortex Choline O-Acetyltransferase Enzyme Induction Nerve Growth Factors Peptides, Cyclic Presynaptic Terminals Proto-Oncogene Proteins Rats Rats, Sprague-Dawley Receptor Protein-Tyrosine Kinases Receptor, trkA Receptors, Nerve Growth Factor Synapses Journal Article Research Support, Non-U.S. Gov't

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T Debeir, H U Saragovi, A C Cuello. TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo.. https://doi.org/10.1016/s0928-4257(98)80011-9

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