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PubMed · 9680183

Chronic ethanol feeding induces cellular antioxidants decrease and oxidative stress in rat peripheral nerves. Effect of S-adenosyl-L-methionine and N-acetyl-L-cysteine.

F Bosch-Morell·F Martínez-Soriano·A Colell·J C Fernández-Checa·F J Romero
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Abstract

Chronic ethanol feeding promotes oxidative stress in rat peripheral nerve. Malondialdehyde, a lipid peroxidation product, content increases in sciatic nerves of rats fed an ethanol-containing diet, when compared with pair-fed animals. Moreover, glutathione content and glutathione peroxidase activity in this same tissue decrease in ethanol-fed vs. pair-fed rats. S-Adenosyl-L-methionine and N-acetyl-L-cysteine, both with possible therapeutic action on alcoholism, were tested in this animal model. Only N-acetyl-L-cysteine was able to normalize malondialdehyde content and to restore glutathione content and glutathione peroxidase activity, to values not significantly different from those of sciatic nerves from pair-fed animals. The reasons for the different effect of both substances tested is also discussed.

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AcetylcysteineAnimalsAntioxidantsEthanolGlutathioneGlutathione PeroxidaseLipid PeroxidationMaleMalondialdehydeMicroscopy, ElectronOxidative StressPeripheral NervesRatsRats, Sprague-DawleyS-AdenosylmethionineJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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F Bosch-Morell, F Martínez-Soriano, A Colell, J C Fernández-Checa, F J Romero. 1998. Chronic ethanol feeding induces cellular antioxidants decrease and oxidative stress in rat peripheral nerves. Effect of S-adenosyl-L-methionine and N-acetyl-L-cysteine.. https://doi.org/10.1016/s0891-5849(98)00036-7

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