Enzyme models: design and selection.

S J Rowan; J K Sanders

doi:10.1016/s1367-5931(97)80042-7

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Enzyme models: design and selection.

S J Rowan·J K Sanders

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Abstract

There are two approaches to the discovery of enzyme mimics, that is identifying molecules that are able to bind substrate(s) and then catalyse reactions. The first approach, often inspired by enzymes themselves, utilises chemical knowledge and experience to design the catalyst. The other approach is to create a library and select the best host of a transition state analogue of the required reaction.

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Base Sequence Binding Sites Catalysis Drug Design Enzymes Models, Chemical Models, Molecular Molecular Conformation Molecular Sequence Data Nucleic Acid Conformation Peptide Library Protein Conformation RNA, Catalytic Journal Article Review

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S J Rowan, J K Sanders. 1997. Enzyme models: design and selection.. https://doi.org/10.1016/s1367-5931(97)80042-7

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