Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 9532340

Management guidelines for hyperthyroidism.

J A Franklyn
View original source ↗Export metadata ↓

Abstract

Anti-thyroid drugs, surgery and radioiodine all represent effective forms of treatment for Graves' hyperthyroidism. There is, however, little consensus regarding the treatment of choice for specific cases. This lack of consensus prompted the development of guidelines for good practice in the management of hyperthyroidism for the United Kingdom. This chapter describes the process of development of this United Kingdom consensus statement, and associated audit measures, and highlights outstanding contentious issues in the management of Graves' hyperthyroidism.

Explore related subjects

Antithyroid AgentsHumansHyperthyroidismIodine RadioisotopesMedical AuditPractice Guidelines as TopicJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J A Franklyn. 1997. Management guidelines for hyperthyroidism.. https://doi.org/10.1016/s0950-351x(97)80783-5

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2000

[Reversible pulmonary hypertension in Basedow's disease].

BACKGROUND: An association between pulmonary hypertension and hyperthyroidism has been described. An autoimmune mechanism is usually advocated but a direct effect thyroid hormones on the pulmonary vascular system is also suggested. CASE REPORT: A 49-year-old woman with a history of Graves' disease was admitted for sudden dyspnea. There was no evidence of ischemic stroke and the electrocardiogram and cardiac enzymes were normal. The lung scintiscan did not show any sign of pulmonary embolism. The chest computed tomography was normal. Doppler echocardiography found pulmonary hypertension with systolic pulmonary artery pressure of 68.7 mmHg. Thyroid function tests showed hyperthyroidism with recurrent Graves' disease. Pulmonary hypertension markedly decreased after the euthyroid state was achieved with antithyroid therapy. DISCUSSION: This patient had pulmonary hypertension associated with hyperthyroidism due to Graves' disease. The rapid reversibility of pulmonary hypertension in this case after the achievement of the euthyroid state suggest a pathogenic link between these two disorders and a possible direct effect of thyroid hormones on the pulmonary vascular system.

Antithyroid Agents↗
PubMed2000

Stability of propylthiouracil in extemporaneously prepared oral suspensions at 4 and 25 degrees C.

The stability of propylthiouracil in two extemporaneously prepared suspensions at 4 and 25 degrees C was studied. Commercially available 50-mg propylthiouracil tablets were used to prepare suspensions in 1:1 Ora-Sweet:Ora-Plus and in 1:1 1% methylcellulose:Simple Syrup, NF, to yield a propylthiouracil concentration of 5 mg/mL. Each suspension was stored in 10 amber plastic prescription bottles, 5 of them at 4 degrees C and the other 5 at 25 degrees C. Three samples were taken from each bottle at 0, 7, 14, 28, 42, 56, 70, and 91 days for assay by stability-indicating high-performance liquid chromatography. More than 90% of the initial propylthiouracil concentration was retained in both suspensions for 70 days at 25 degrees C and for 91 days at 4 degrees C. There were no changes in physical appearance, color, or odor, and the pH remained essentially unchanged. Propylthiouracil 5 mg/mL in two extemporaneously prepared oral suspensions was stable for at least 70 days at 25 degrees C and for at least 91 days at 4 degrees C.

Antithyroid Agents↗