PubMed · 9509713
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A A Heiger. 1998. Round table discussion.. https://pubmed.ncbi.nlm.nih.gov/9509713/
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BACKGROUND: To evaluate whether antral biopsies are enough for confirming Helicobacter pylori eradication with the "new" one week triple therapies with omeprazole. PATIENTS AND METHODS: 229 duodenal ulcer patients were treated with omeprazole for 7 days plus two antibiotics. Eradication was confirmed with histology (two biopsies from both gastric antrum and body) and 13C-urea breath test one month after the end of therapy. RESULTS: H. pylori eradication was achieved in 76.9% of the patients (95% CI: 71-82%). Histology at antrum was highly reliable to detect eradication failure: in all but in one case in which H. pylori was observed at gastric body, was the microogranism also observed at antrum. Infection prevalences at both locations were not homogeneous (McNemar: 6.4; p < 0.05). Concordance between antral biopsies and breath test for H. pylori diagnosis after therapy was excellent (kappa: 0.91; SE: 0.07), and both prevalences were homogeneous (McNemar: 1.3; p > 0.05). CONCLUSIONS: Taking antral biopsies is enough for confirming H. pylori eradication with the "new" one week triple therapies.
Gastric mucosa associated lymphoma (MALT) can be regarded as a pathogenetic continuum of reactive B lymphocyte accumulation due to Helicobacter pylori infection, which after a series of mutation may presumably transform into a low grade and later on into a high grade MALT lymphoma. If the lymphoma is confined to the mucosa or strictly to the superficial part of gastric wall, a conventional, regular Helicobacter pylori eradication procedure has a good chance to bring about clinical, histological and less frequently molecular biological remission as well.