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PubMed · 9506890

The pre-UV nutritional stresses increase UV resistance, decrease UV mutagenesis and inhibit excision repair.

V Slezarikova·F Masek·M Pirsel·M Sedliakova
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Abstract

Nutritional stresses applied to E. coli prior to UV irradiation increase UV resistance and decrease UV mutagenesis. This effect is uvrA-dependent and might reflect a more efficient excision of pyrimidine dimers [1]. The data presented here, however, indicate that after prestarvation for glucose or amino acids pyrimidine dimer excision (PDE) was partly inhibited. It appears that the stress conditions stimulate a mode of uvr-dependent tolerance of lesions, efficient and precise. Possible modes of PDE inhibition and lesion tolerance are discussed.

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Adenosine TriphosphatasesAmino AcidsBacterial ProteinsChromatography, PaperDNA RepairDNA, BacterialDNA-Binding ProteinsEndonucleasesEscherichia coliEscherichia coli ProteinsGlucoseMutagenesisThymineUltraviolet RaysJournal ArticleResearch Support, Non-U.S. Gov't

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V Slezarikova, F Masek, M Pirsel, M Sedliakova. 1997. The pre-UV nutritional stresses increase UV resistance, decrease UV mutagenesis and inhibit excision repair.. https://doi.org/10.1016/s0921-8777(97)00044-x

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