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PubMed · 9453805

[How to develop a quality system].

P Roussel
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Abstract

When principles relating to quality assurance are known and understood, they must still be practically and progressively implemented. Many complementary actions are described for the building of a quality system in a blood bank. The aim is to control the quality organization, operational processes and the ensuing documentary system. Some critical points about the development of a quality system and its timelessness are then discussed.

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Blood BanksDelivery of Health CareDocumentationQuality Assurance, Health CareTotal Quality ManagementEnglish AbstractJournal Article

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P Roussel. 1997. [How to develop a quality system].. https://doi.org/10.1016/s1246-7820(97)80062-6

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Cell age-related monovalent cations content and density changes in stored human erythrocytes.

Conversion of erythrocyte membrane protein 4.1b to 4.1a occurs through a non-enzymatic deamidation reaction in most mammalian erythrocytes, with an in vivo half-life of approximately 41 days, making the 4.1a/4.1b ratio a useful index of red cell age [Inaba and Maede, Biochim. Biophys. Acta 944 (1988) 256-264]. Normal human erythrocytes distribute into subpopulations of increasing cell density and cell age when centrifuged in polyarabinogalactan density gradients. We have observed that, when erythrocytes were stored at 4 degrees C under standard blood bank conditions, the deamidation was virtually undetectable, as cells maintained the 4.1a/4.1b ratio they displayed at the onset of storage. By measuring the 4.1a/4.1b values in subpopulations of cells of different density at various time points during storage, a modification of the normal 'cell age/cell density' relationship was observed, as erythrocytes were affected by changes in cell volume in an age-dependent manner. This may stem from a different impact of storage on the imbalance of monovalent cations, Na(+) and K(+), in young and old erythrocytes, related to their different complement of cation transporters.

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