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PubMed · 9434869

Does aneuploidy per se cause developmental abnormalities?

J H Ford
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Abstract

The following questions are addressed: (A) What are aneuploidogens and how do they act? (B) Is there any evidence that aneuploidy per se causes malformations? (C) What examples are there of abnormalities, apparently attributable to aneuploidogens acting as teratogens? (D) Do abnormalities of cell division cause both teratogenesis and aneuploidy? Considerable research has addressed question (A), but there is little which addresses the other three questions. The question of whether aneuploidy per se causes malformations remains open. Some suggestions for further research are made.

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AneuploidyAnimalsCell DivisionChromosome AberrationsChromosome DisordersCongenital AbnormalitiesEmbryonic and Fetal DevelopmentFemaleHumansMaleMeiosisMutagensPregnancyPregnancy ComplicationsTeratogensJournal ArticleReview

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BibTeXRIS

J H Ford. 1997-12-12. Does aneuploidy per se cause developmental abnormalities?. https://doi.org/10.1016/s0027-5107(97)00184-x

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