PubMed · 9418560
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M E Mathiesen. 1997-11-11. [Adoption can be difficult].. https://pubmed.ncbi.nlm.nih.gov/9418560/
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The aim of this study was to find potential signs of genetic vulnerability to schizophrenia. The differences between adoptees at high genetic risk for schizophrenia (their biological mother had a schizophrenia spectrum disorder) and control adoptees of non-schizophrenia spectrum biological mothers were assessed. The comparisons between these groups were based on the Minnesota Multiphasic Personality Inventory (MMPI) test's subscale scores adjusted by gender, age at MMPI assessment, age at placement into the adoptive family and social class. The subjects were a subsamples of a total of 182 tested adoptees and 136 mentally healthy adoptees in the Finnish Adoptive Family Study. The high-risk group was found to be distinguishable from the low-risk group based on deviant scores on the Hostility, Hypomania and Lie scales. These scales may measure genetic vulnerability and also possibly be indicative of psychometric deviance predicting future onset of schizophrenia.
BACKGROUND: Thought disturbances are commonly associated with psychiatric disorders, especially schizophrenia. Our aim was to clarify whether thought disorders are only stable at certain severity levels and in the presence of certain schizophrenia factors of the Thought Disorder Index (TDI) scale. Furthermore, we also examined the significance of genetic status and the psychiatric disorder for the persistence of TDI severity levels and factors. METHODS: The thought disorders of 158 adoptees genetically at high-risk or low-risk for schizophrenia participating the Finnish Adoptive Family Study of Schizophrenia were evaluated twice at a mean interval of 11 years. Thought Disorder Index (TDI) was used to assess the severity levels and schizophrenia factors. TDI identifies 23 different items of thinking disturbances, which are weighted along a continuum of severity. RESULTS: Thought disorders at the 0.50 and 0.75 severity levels and idiosyncratic verbalization indicative of the schizophrenia factors turned out to be stable phenomena throughout the follow-up period. The adoptees' genetic or psychiatric status was not associated with the results. CONCLUSIONS: The study shows that the stability of TDI seems to be related to the most severe categories of thought disorders. However, of the specific schizophrenia factors, idiosyncratic verbalization, but not confusion and fluid thinking, showed stability over time. Although idiosyncratic verbalization does not necessarily represent the most severe type of thought disturbance, it turned out relatively stable and we can speculate that idiosyncratic verbalization have some predictive value, too.
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