PubMed · 9417639
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E E Fetz. 1997-12-12. Temporal coding in neural populations?. https://doi.org/10.1126/science.278.5345.1901
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We describe that tetanus-induced long-term increase of the response amplitude in one input to an identified neuron is accompanied by a decrease of synaptic responses in another, non-tetanized input. Induction of the decrease of responses in non-tetanized inputs was prevented by bath application of protein synthesis blockers (anisomycin or cycloheximide). The decrease of responses also did not occur in experiments when tetanization was substituted by short-term serotonin applications or extracellular stimulation of serotonergic cells known to potentiate investigated synaptic inputs. The results suggest that the heterosynaptically evoked decrease of synaptic response amplitude may be due to involvement of postsynaptic protein synthesis-dependent mechanisms.
Dopaminergic and non-dopaminergic neurons of the ventral tegmental area (VTA) were recorded intracellularly in slices of rat midbrain. Glycine (0.1-3 mM) caused a strychnine-sensitive and chloride-dependent reduction in membrane input resistance in both types of neuron. However, glycine also reduced the frequency of spontaneous bicuculline-sensitive inhibitory postsynaptic potentials (IPSPs) when recorded in dopaminergic cells. We conclude that glycine inhibits both types of VTA neuron by activating a strychnine-sensitive chloride conductance. Our data also raise the possibility that glycine could increase dopamine output from the VTA by a mechanism of disinhibition.
A strategy based upon a comparative decrease in bilateral symmetry of cytochrome oxidase (COX) histochemistry following unilateral eye enucleation was used to identify the primary visual area in the area dorsalis of the telencephalon of the goldfish, Carassius auratus. The lateral zone of area dorsalis (Dl) at about the level of the anterior commissure exhibits such a bilateral difference. A parallel decline in the symmetry COX reactivity was observed in the associated part of the central zone (Dc). Electrophysiological activity using extracellular techniques confirmed the visually-driven activity of neurons in these areas. Lesions confirmed the loci in the lateral zone of area dorsalis, including both its dorsal and ventral parts. Single- and multi-unit recordings exhibited a variety of responses to different light stimuli. Single unit latency measures proved not to be a reliable measure of target areas. Responses habituated to stimuli repeated within 5 s and were only reliably evoked with intervals greater than several seconds.