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PubMed · 9297528

MHC class I antigen processing pathways.

A Maffei·K Papadopoulos·P E Harris
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Abstract

The multistep process that culminates in major histocompatibility complex (MHC) class I presentation of foreign of self-peptides begins in the last phases of protein catabolism. Although the individual roles of many key molecules-such as proteasomes, the transporter associated with antigen processing, and various endoplasmic reticulum chaperones-have recently been elucidated, there still remain many questions regarding processing of proteins into MHC class I bound peptides. This review summarizes the recent developments in antigen processing for MHC class I molecules, with a focus on how proteins are believed to be sampled and selected for degradation.

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Antigen PresentationHLA AntigensHistocompatibility Antigens Class IHumansMajor Histocompatibility ComplexPeptidesJournal ArticleReview

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A Maffei, K Papadopoulos, P E Harris. 1997. MHC class I antigen processing pathways.. https://doi.org/10.1016/s0198-8859(97)00084-0

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