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PubMed · 9206213

[A study on acute multiple sclerosis].

C Lu·Z Li·Y Xu
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Abstract

With the purpose of investigating the clinicopathological changes and the criterion for differential diagnosis, ten cases of Acute multiple sclerosis (AMS) were analysed. The data suggested that its clinical course was an acute neurologic event characterized by psychic syndrome, paralysis and incontinence of bowel movement and urination. Pathologically, the demyelination lesion consisted of three patterns, i.e.: vascullar or spongy lesions, shadow plaques and liquefaction or necrosis. One of the above forms could exist individually or coexist with the others. The accurate diagnosis was made only after autopsy. Criterion for the differential diagnosis between AMS and ADEM were discussed.

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Acute DiseaseAdultBrainDiagnosis, DifferentialEncephalomyelitis, Acute DisseminatedFemaleHumansMaleMultiple SclerosisRetrospective StudiesEnglish AbstractJournal Article

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C Lu, Z Li, Y Xu. 1996. [A study on acute multiple sclerosis].. https://pubmed.ncbi.nlm.nih.gov/9206213/

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BACKGROUND: Polymyalgia rheumatica (PMR) is a systemic inflammatory disease of unknown cause that affects older individuals. Clinical symptoms respond promptly to corticosteroids, but treatment is often required for several years, frequently resulting in adverse drug effects. Guidelines for the optimal use of corticosteroids that maximize relief of symptoms but minimize adverse effects of the therapy are needed. OBJECTIVE: To determine whether clinical or laboratory parameters in PMR could be identified that allow for stratifying patients into subsets with differences in corticosteroid requirements. PATIENTS AND METHODS: We studied 27 patients with PMR treated with a standardized schedule of prednisone. Patients were reevaluated at monthly intervals for pain scores and physician and patient assessments. Plasma interleukin 6 level and the erythrocyte sedimentation rate were measured at each visit. The duration of steroid therapy and the cumulative steroid dose were calculated. RESULTS: Based on the initial response to therapy and the duration of disease, the 27 patients could be subdivided into 3 distinct groups. Eight with low erythrocyte sedimentation rates responded rapidly and required corticosteroids for less than 1 year with rare disease flares on tapering of prednisone. Twelve others responded well initially but did not tolerate reduction to lower doses and had remitting disease of more than 1 year. Seven patients had only a partial response to the initial steroid regimen. After 4 weeks of therapy, the erythrocyte sedimentation rates improved, but levels of interleukin 6 remained elevated. Pretreatment pain scores were also higher in these partial responder patients (P = .05). CONCLUSIONS: Polymyalgia rheumatica is a heterogeneous disease with variations in the treatment duration and dose of corticosteroids required for suppression of symptoms. Pretreatment erythrocyte sedimentation rate and nonresponsiveness of interleukin 6 to steroid therapy are helpful in dividing patients into subsets with different treatment requirements.

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