PubMed · 9123675
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H Schulze. 1997. [Benign prostatic hyperplasia].. https://doi.org/10.1007/s001200050059
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The 35% EtOH extract of aerial parts of Impatiens balsamina L. has been investigated for activity against testosterone 5alpha-reductase. Activity-guided fractionation led to the identification of the bisnaphthquione derivative named impatienol (1), 3-hydroxy-2-¿[3-hydroxy-1,4-dioxo (2-naphthyl)] ethyl¿ naphthalene-1, 4-dione, which exhibited significant testosterone 5alpha-reductase inhibitory activity. This 5alpha-reductase inhibitory compound has been previously synthesized, but this is the first report of its isolation from a natural source.
The methanol extract of heartwood of Artocarpus incisus showed potent 5 alpha-reductase inhibitory activity. We investigated the 5 alpha-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 microM) and artocarpin (IC50 = 85 microM) showed more potent inhibitory effects than did alpha-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5 alpha-reductase inhibitory effects.