A mammalian bicistronic transcript encoding two dentin-specific proteins.

H Ritchie; L H Wang

doi:10.1006/bbrc.1997.6126

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A mammalian bicistronic transcript encoding two dentin-specific proteins.

H Ritchie·L H Wang

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Abstract

We previously reported that the cDNA for dentin phosphophoryn, a non-collagenous protein involved in dentin mineralization, was located immediately downstream from the 3' end of dentin sialoprotein, another functionally related non-collagenous dentin protein (Ritchie, H. H., and Wang, L-H. (1996) J. Biol. Chem. 269, 3689-3702). We now demonstrate unequivocally that at the genomic level in mammal, these two functionally related proteins are indeed transcribed as one transcriptional unit suggesting that their combined presence at specific mineralization sites in tooth germ is mandatory if dentin mineralization is to proceed.

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Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA, Complementary Exons Extracellular Matrix Proteins Introns Molecular Sequence Data Phosphoproteins Protein Precursors RNA, Messenger Rats Sialoglycoproteins Dentin Sialophosphoprotein Journal Article Research Support, U.S. Gov't, P.H.S.

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H Ritchie, L H Wang. 1997-02-13. A mammalian bicistronic transcript encoding two dentin-specific proteins.. https://doi.org/10.1006/bbrc.1997.6126

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