Lac repressor-operator complex.

M A Kercher; P Lu; M Lewis

doi:10.1016/s0959-440x(97)80010-3

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PubMed · 9032054

Lac repressor-operator complex.

M A Kercher·P Lu·M Lewis

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Abstract

For many years the lac operon of Escherichia coli has been the paradigm for gene regulation. Recently, the structures of the lac repressor core bound to isopropyl-beta-D-1-thiogalactoside (IPTG), the intact apo lac repressor, the intact lac repressor complexes with IPTG and a 21-base-pair symmetric operator, and the refined headpiece of the repressor have been determined. These structures have provided a framework for understanding a wealth of biochemical and genetic information. An analysis of these structures, as well as a description of their function and a comparison to homologous proteins, is now possible.

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Allosteric Regulation Bacterial Proteins Binding Sites Escherichia coli Proteins Lac Operon Lac Repressors Protein Binding Repressor Proteins Journal Article Review

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M A Kercher, P Lu, M Lewis. 1997. Lac repressor-operator complex.. https://doi.org/10.1016/s0959-440x(97)80010-3

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