PubMed · 8999128
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N Kuriya. 1996. [Problems on medical statistical process--wrong application].. https://pubmed.ncbi.nlm.nih.gov/8999128/
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"Regression to the mean" (RTM) is a statistical phenomenon originating from the random variation of variables rather than a true association between the variables. RTM is closely linked to mathematical coupling; unawareness of these phenomena may lead to misinterpretation of data. A study examining intracranial pressure before and after infusion of manitol is presented, in which mathematical coupling caused a highly significant (but spurious) correlation between the analysed data. The significance of RTM and mathematical coupling is demonstrated by analysis of a data set derived from random numbers.
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