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PubMed · 8906751

HIV disease in children is associated with a selective decrease in CD23+ and CD62L+ B cells.

C Rodriguez·J K Thomas·S O'Rourke·E R Stiehm·S Plaeger
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Abstract

We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude that, despite persistent high immunoglobulin levels, total B cells decreased as HIV disease progressed, with selective decreases in CD62L+ and CD23+ B cells. This resulted in an increased proportion of usually minor subpopulations of CD62L- and CD23-negative B cells. We did not find significantly altered B cell expression of other activation/immaturity antigens. This suggests an absolute decrease in a subset of antigen-responsive B cells and a disproportionate increase in a subset of hyperstimulated B cells. These findings provide a biological basis for the paradoxical generalized B cell hyperactivity and specific immune unresponsiveness that are characteristic of HIV infection in children.

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Antigens, CDAntigens, CD19Antigens, Differentiation, B-LymphocyteB-Lymphocyte SubsetsB-LymphocytesChildChild, PreschoolFemaleHIV InfectionsHumansHypergammaglobulinemiaInfantL-SelectinLymphocyte CountMaleNeprilysinPhenotypeReceptors, IgEReceptors, TransferrinJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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C Rodriguez, J K Thomas, S O'Rourke, E R Stiehm, S Plaeger. 1996. HIV disease in children is associated with a selective decrease in CD23+ and CD62L+ B cells.. https://doi.org/10.1006/clin.1996.0176

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