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PubMed · 8904166

Cellular interactions in hemostasis.

M Hoffman·D M Monroe·H R Roberts
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Abstract

Coagulation reactions normally occur on cell membranes in vivo. Using a cell-based in vitro model system, we have shown that where a factor is located, not simply how much is activated, is critically important in determining its role in hemostasis. Factor Xa activated on a tissue factor (TF)-bearing cell is not equivalent to factor Xa activated on a platelet surface. Factor IX and factor VIII are required for hemostasis because they combine to generate factor Xa on the platelet surface. Factor X activation by factor VIIa/TF does not compensate for a lack of factor IX or VIII because the factor Xa activated by VIIa/TF is located on the wrong surface for efficient thrombin generation.

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Blood CoagulationCell CommunicationFactor IXFactor VIIIHemostasisHumansIn Vitro TechniquesModels, BiologicalThromboplastinJournal ArticleReview

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M Hoffman, D M Monroe, H R Roberts. 1996. Cellular interactions in hemostasis.. https://doi.org/10.1159/000217233

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