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PubMed · 8818586

Galanthamine.

B Fulton·P Benfield
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Abstract

Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue. Galanthamine attenuates drug-and lesion-induced cognitive deficits in animal models of learning and memory. Preliminary results in patients with Alzheimer's disease have reported galanthamine to be associated with a reduction in cognitive deterioration on some neuropsychiatric rating scales. Nausea and vomiting are the most commonly reported adverse effects; liver toxicity has not been reported to date.

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Alzheimer DiseaseAnimalsCholinesterase InhibitorsClinical Trials as TopicGalantamineHumansJournal ArticleReview

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BibTeXRIS

B Fulton, P Benfield. 1996. Galanthamine.. https://doi.org/10.2165/00002512-199609010-00006

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