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PubMed · 8804532

Sculpted immunogens; B-cell epitope optimization using constrained secondary structure libraries.

J Urban·M Qabar·C Sia·M Klein·M Kahn
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Abstract

A library of conformationally constrained reverse turn mimetics of the HIV V3 loop was screened against the mAb 50.1. Addition of a Th-cell epitope to the reverse turn template provided an immunogen which, when immunized (either in alum or IFA), generated a high titer, highly specific response to HIV gp 120.

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Adjuvants, ImmunologicAmino Acid SequenceAnimalsConsensus SequenceEnzyme-Linked Immunosorbent AssayEpitopes, B-LymphocyteGuinea PigsHIV AntigensHIV Envelope Protein gp120HIV-1Molecular Sequence DataPeptide FragmentsProtein Structure, SecondaryVaccines, SyntheticComparative StudyJournal Article

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J Urban, M Qabar, C Sia, M Klein, M Kahn. 1996. Sculpted immunogens; B-cell epitope optimization using constrained secondary structure libraries.. https://doi.org/10.1016/0968-0896(96)00062-4

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