PubMed · 8753599
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Y Orita, H Nakahama. 1995. [Diuretics].. https://pubmed.ncbi.nlm.nih.gov/8753599/
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The NHIK 3025 cell line (Norsk Hydro Institutt for Kreftforskning), a human in situ carcinoma of the cervix cell line, was used to investigate the thiazides bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide and xipamide for their potential phototoxic properties. Cell death following UVA irradiation and dependent on test substance concentration was observed in the presence of all the tested substances except chlortalidone, furosemide, indapamide and xipamide. Bendroflumethiazide was phototoxic at concentrations of 0.05 mM and higher; bemetizide, benzylhydrochlorothiazide, bumetanide and hydroflumethiazide were phototoxic at 0.25 mM and higher and butizide, hydrochlorothiazide, piretanide, polythiazide and trichlormethiazide were phototoxic at 0.5 mM and higher.
About 1 out of 14 males and 1 out of 30 females are afflicted with kidney stones. In many of these patients, the disease is recurrent. Fortunately, our understanding of the disease and ability to treat renal stone disease has increased in the last decade. Parenteral NSAIDs have been shown to be as effective as narcotics in treating renal colic. Dietary and drug therapy after proper metabolic evaluation of patients with recurrent stones is beneficial in reducing the recurrence rate. New understanding of the role of diet and many organic inhibitors of crystallization in urine will further broaden the scope of management of this common disease.