Search PubMed⌕ Search

PubMed · 8745686

[Autochthonal leprosy].

Abstract

INTRODUCTION: In continental France, Hansen's disease is now a strictly imported disease. Native contamination is rare since the foyers described early in the century have totally disappeared. CASE REPORT: A case of locally acquired diffuse lepromatous Hansen's disease was observed in a patient who developed acrocyanosis with distal necrosis over a period of several years. Late cutaneomucal signs led to the diagnosis of Hansen's disease after eliminating sarcoidosis and tuberculosis. Skin biopsy with Ziehl stain confirmed the lepromatous nature of the disease. In addition the patient had undergone splenectomy following trauma and also developed babesiasis (a rare protozoan disease in Europe--15 cases reported--similar to Texas fever). DISCUSSION: The source of infection in this case of Hansen's disease was not found. As in the other cases reported in the literature, late diagnosis due to lack of any suggestive context allowed the disease to develop into an advanced stage.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M N Cormier-Lebreton, P Célérier, C Pasquiou. 1995. [Autochthonal leprosy].. https://pubmed.ncbi.nlm.nih.gov/8745686/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Predictive value of serum immunosuppressive acidic protein for lung metastasis after amputation of murine osteosarcoma of the lower limb.

A spontaneously occurring murine osteosarcoma cell line (POS-1) was inoculated into the footpads of 88 mice. In 59 mice, the tumor-bearing leg was amputated at 1, 3, 5, or 7 weeks after inoculation and the mice sacrificed at 9 weeks. Lung metastasis was observed in 82.6-100% of the mice undergoing leg amputation at 5 or 7 weeks after inoculation. There were no lung metastasis in the mice amputated at 1 or 3 weeks. The serum immunosuppressive acidic protein (IAP) concentration showed a significant increase at 5 or 7 weeks after inoculation (P<0.005 and P<0.0005, respectively). When amputation was done 5 weeks after inoculation, the serum IAP concentration increased further to 5.9 times the pre-amputation level 1 week after the amputation. The IAP concentration increased only 1.3-fold in the control group without inoculation. Thus, a high serum IAP concentration before amputation and a further increase after amputation were indicators of lung metastasis in this mouse model of osteosarcoma.

Amputation, Surgical↗

[Hand transplantation and implantation of nerve chips. New developments within hand surgery].

Injuries and diseases of the hand naturally have an enormous impact on hand function and on quality of life, both occupational and social. The majority of hand-injury patients are under 30 years of age. Hand surgery, an established specialty in Sweden since 1969, is of great importance in terms of clinical developments, education and research. In the coming decade, scientific and clinical advances are to be expected in several fields such as nerve injuries including brachial plexus lesion, microsurgery, flexor tendon injuries and tendon transfer. Bioimplant research and new advances at the biotechnological interface will yield new options in nerve reconstruction, microchip implants in the nervous system, and the restoration of muscle-tendon function following injury. Artificial limbs with advanced motor and sensory functions will be important future aids in the rehabilitation of amputees. Transplantation of human hands is another promising reconstructive procedure which may open iup new perspectives in the coming millennium.

Amputation, Surgical↗