The interferons.

Abstract

OBJECTIVE: To provide a review of the biology, pharmacology, clinical application, and toxic effects of interferon and strategies for nursing management. DATA SOURCES: Research studies, review articles, and book chapters pertaining to interferons. CONCLUSIONS: Interferons are active therapeutic agents for hairy cell leukemia, chronic myelogenous leukemia, melanoma, and acquired immunodeficiency syndrome-related Kaposi's sarcoma. Clinical trials continue to investigate the clinical application of interferons. IMPLICATIONS FOR NURSING PRACTICE: Oncology nurses can facilitate patient self-care in managing side effects of interferon therapy, provide patient and family education, and assist with reimbursement concerns.