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PubMed · 8721683

Clonal chromosome abnormalities in two chemodectomas.

Y Jin·F Mertens·C Jin·J Wennerberg·N Mandahl·S Heim·F Mitelman
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Abstract

Short-term cultures from two histologically benign chemodectomas, one from the carotid body and one from the vagal nerve, were analyzed cytogenetically. The former had a small abnormal clone with the karyotype 46,XX,t(3;19)(q21;q13),t(12;15) (p13;q12-14), whereas the majority of the cells from the latter tumor displayed two related abnormal clones: 46,XY,i(I)(q10)/ 46,iderm,add(2)(q37). The findings add to the evidence that chemodectomas are heterogeneous neoplasms and suggest that the heterogeneity may possibly be associated with the site of origin.

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Carotid Body TumorChromosome AberrationsChromosome DisordersFemaleHumansKaryotypingMaleMiddle AgedNeoplasms, Nerve TissueParaganglioma, Extra-AdrenalTumor Cells, CulturedVagus NerveCase ReportsJournal ArticleResearch Support, Non-U.S. Gov't

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Y Jin, F Mertens, C Jin, J Wennerberg, N Mandahl, S Heim, F Mitelman. 1996. Clonal chromosome abnormalities in two chemodectomas.. https://doi.org/10.1002/(sici)1098-2264(199603)15%3A3%3C178%3A%3Aaid-gcc6%3E3.0.co%3B2-%23

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