PubMed · 8716467
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R Raghavan. Learning disabilities. Confusing diagnoses.. https://pubmed.ncbi.nlm.nih.gov/8716467/
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Primary hyperparathyroidism is diagnosed with increasing incidence. Many patients are misinterpreted as being asymptomatic, but they do indeed suffer from a broad variety of non-specific symptoms. Investigations show that patients with primary hyperparathyroidism may be lethargic, apathic, demented and depressed. Many suffer from bone and joint pain. Surgical treatment can be done with few complications and a high cure rate, resulting in reversal of symptoms. Since symptoms do not correlate with S-Ca++ or S-parathyroid hormone and since the symptoms can be attributed to many other causes, we need more research to find those patients, who will benefit from surgical treatment.
Patients with primary hyperparathyroidism (PHPT) often suffer from muscle and bone pain, are often easily fatigued and may show depressive signs. We present a case of a 50 year-old man with PHPT with muscle pain and fatigue. After parathyroidectomy the symptoms resolved. Preoperatively he had a normal serum-parathyroid hormone (PTH) and an increased ionized serum-calcium. Postoperatively the PTH level increased, though still within the normal range.