[Pentoxifylline].

P T Paradowski; K Zeman

Home/Archive/PubMed

PubMed · 8657627

[Pentoxifylline].

P T Paradowski·K Zeman

View original source ↗Export metadata ↓

Abstract

Pentoxifylline (PTX), methylxanthine derivative and phosphodiesterase inhibitor, has been in use for more than 20 years (with minimal side effects) for the potent hemorrheologic properties and was recently discovered to have influence on function of some immune cells and production of cytokines. Human and animal studies have shown that PTX therapy results in a variety of physiologic changes at the cellular level, which may be important in treating a diverse group of human afflictions. Immune modulation includes increased leukocyte deformability and chemotaxis, decreased endothelial leukocyte adhesion, decreased neutrophil degranulation and release of superoxides, decreased production of TNF-alpha and decreased NK cell activity. Potential medical uses of PTX are reviewed.

Explore related subjects

Acquired Immunodeficiency Syndrome Animals Autoimmune Diseases Humans Immunity, Cellular Killer Cells, Natural Liver Cirrhosis Neutrophils Pentoxifylline Phosphodiesterase Inhibitors Tumor Necrosis Factor-alpha English Abstract Journal Article Review

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

P T Paradowski, K Zeman. 1995. [Pentoxifylline].. https://pubmed.ncbi.nlm.nih.gov/8657627/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2000

Drug abuse, methadone treatment, and health services use among injection drug users with AIDS.

This paper compares health care use across subgroups of injection drug users (IDUs) with AIDS, as defined by current drug abuse status and participation in methadone maintenance treatment (MMT), using surveillance-identified IDU status and health care claims data. Merged Medicaid and AIDS surveillance data were analyzed using ordinary least squares regression, simple logistic regression and multinomial logistic regression. Consistent MMT was more likely among women, Whites and older subjects. Monthly total expenditures and inpatient expenditures were significantly lower for IDUs in MMT than for IDUs with claims indicative of current drug abuse. Consistent participation in MMT was associated with a higher probability of antiretroviral use and, among antiretroviral users, more consistent use of antiretrovirals. Merged administrative data sets can be an important data source that illuminate the relationships among drug abuse, drug treatment, and HIV-related health care. For AIDS-infected IDUs, consistent MMT may lower barriers to receipt of appropriate HIV-related health care and reinforce adherence to medical recommendations.

Acquired Immunodeficiency Syndrome↗

PubMed2000

Is the United States country zero for the First-World AIDS epidemic?

The incidence for AIDS per hundred thousand is several times higher in the United States than in the rest of the First World. Earlier work by Thompson (1984, 1989a, b, 1990, 1998) indicated that a relatively small proportion of gay males frequenting the bathhouses in the United States, drove AIDS over the epidemiological threshold in the U.S. It is shown that the rate of growth of AIDS is essentially the same for the United States and other First-World countries. An argument is advanced, based on WHO AIDS data, to the effect that it is contact with the pool of infectives in the United States that drives the epidemic in other First-World Countries.

Acquired Immunodeficiency Syndrome↗

PubMed2000

Bridging the gap: human diploid cell strains and the origin of AIDS.

Recent descriptions of the first human and chimpanzee cases of human immunodeficiency virus type 1 (HIV-1)-related retroviral infections dating from 1959 have stirred interest in the origin of AIDS. Although the theory of a chimpanzee origin of HIV-1 with cross-species transfer to man has now gained popularity, a more likely scenario is that chimps and humans were infected by an HIV-1 precursor virus derived from a contaminated poliovaccine. The reason for the rapidity and ease of cross-species transfer of this precursor virus has not been elucidated. We hypothesize that the poliovaccine was passaged in a human diploid cell strain. This simple manipulation allowed the retrovirus to adapt to human tissues and may have spawned the AIDS pandemic.

Acquired Immunodeficiency Syndrome↗