Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 8650438

Platelet-associated bleeding disorders.

K M Shuey
View original source ↗Export metadata ↓

Abstract

OBJECTIVE: To provide a review of platelet disorders, treatment, and nursing care. DATA SOURCES: Review articles and book chapters pertaining to quantitative and qualitative platelet disorders. CONCLUSIONS: Platelet-associated bleeding disorders are classified as quantitative (abnormal number), qualitative (abnormal function), or hypercoagulable states (errors in hemostasis). The resulting complications include thrombocytosis, thrombocytopenia, hypercoagulation, or bleeding dyscrasias. The administration of drugs, plasma, or platelet therapy may be beneficial to these patients. IMPLICATIONS FOR NURSING PRACTICE: Patients with platelet disorders are at great risk of life-threatening hemorrhage and require close monitoring to prevent unnecessary sequelae. Patient instruction to prevent trauma is required.

Explore related subjects

Blood Platelet DisordersFibrinolysisHumansJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

K M Shuey. 1996. Platelet-associated bleeding disorders.. https://doi.org/10.1016/s0749-2081(96)80015-5

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

[Differential diagnosis of platelet disorders].

Platelet disorders frequently represent a cause of bleeding disorders with a late manifestation and spontaneous bleeding. Disturbances of cellular hemostasis can be of quantitative nature due to an altered production or destruction of platelets. Qualitative disturbances can be associated with defects of adhesion, secretion or degranulation. Drug induced reactions, inflammatory processes and autoimmune reactions are the most frequent underlying disorders. Even a late manifestation, however, does not exclude congenital disorders. In the differential diagnosis of thrombocyte disorders the anamnestic analysis of the clinical circumstances of manifestation, of a family background and potentially interfering drugs are of central importance. Template bleeding time, aggregometry and flow cytometry are complementary methods for the characterization of functional defects. First of all, a von Willebrand syndrome as the most frequent congenital form of a mucocutaneous bleeding pattern needs to be excluded. The clinical context is very important in the analysis of disturbances of platelet turnover. Reticulated platelets allow the quantitative assessment of reduced production or increased destruction. Platelet indices, morphological assessment of blood and bone marrow and immunological tests allow the pathogenetical classification of thrombocytopenia. Idiopathic thrombocytopenia (ITP) is a frequent diagnosis by exclusion. The analysis of glycoprotein expression and the genetic characterization of suspected congenital defects are only performed in selected cases. Clinical and laboratory assessment are complementary in the discrimination of secondary forms of thrombosis from clinically relevant clonal disturbances.

Blood Platelet Disorders↗