PubMed · 8600403
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P Lempert. 1996. Optic disc size.. https://doi.org/10.1016/s0161-6420(96)38044-5
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PURPOSE: The fibroblast growth factors (FGFs) are a family of 9 heparin binding proteins which have been proposed to play key roles in angiogenesis. Basic FGF (bFGF), acidic FGF (aFGF) and FGF5 have previously been demonstrated to be expressed in the normal retina and RPE. In this study, the expression of FGF5 was explored in choroidal neovascular membranes removed from patients with age-related macular degeneration (ARMD). METHOD: Three membranes were surgically removed from patients with ARMD, and were fixed, embedded and sectioned for immunohistochemistry. The membranes were immunostained with an affinity purified rabbit polyclonal antibody raised against the amino acid sequence for residues 175 to 185 of human FGF5 and visualized with the silver enhanced colloidal gold method for light microscopy. RESULTS: FGF5 was expressed in membranes arising from ARMD, and was found primarily in blood vessels and the surrounding extracellular matrix. CONCLUSIONS: These results suggest that FGF5 may have a functional role in the pathophysiology of ARMD.
A patient with a central retinal vein occlusion and cystoid macular edema whose visual acuity was 20/200 was treated with heavy argon laser photocoagulation to a peripheral retinal vein. The patient's visual acuity improved to 20/20. An indocyanine green angiogram performed 5 months following laser therapy showed that a retinal-choroidal venous anastomosis had formed at a point where a large retinal vein crossed over a large choroidal vein. Because indocyanine green angiography can locate large choroidal veins, it may be helpful in guiding this laser treatment.
Macular surgery has made great strides in the past few years, particularly to treat some age-related maculopathies. Epimacular membranes, which occur after posterior vitreous detachment, must be operated if they result in loss of visual acuity, metamorphopsia or disturbance of binocular vision. Visual improvement is obtained in more than 70% of the cases. Macular holes, which are related to a vitreous traction on the macula, can be closed surgically in 70 to 90% of the cases. Choroidal neovascularisation and submacular haemorrhages may be operated on when laser photocoagulation is impossible.