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PubMed · 8590329

Introduction to positional cloning.

N Papadopoulos
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Abstract

The most common procedure for isolating genes that predispose to a certain disease is positional cloning. This process is initiated by mapping the responsible gene to its location on a chromosome linked to the disease. Successive cloning of the region results in the isolation of candidate genes. Finally, identification of mutations by mutational analysis points to the correct gene.

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Chromosome MappingCloning, MolecularDNADNA Mutational AnalysisDNA, ComplementaryGenesGenetic Diseases, InbornGenetic MarkersGenetic VectorsHumansLod ScoreJournal ArticleReview

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BibTeXRIS

N Papadopoulos. 1995. Introduction to positional cloning.. https://doi.org/10.1111/j.1365-2222.1995.tb00438.x

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