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PubMed · 8575835

CD8+ T cell subsets in aging.

M Ruiz·B Esparza·C Pérez·M Barranquero·E Sabino·F Merino
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Abstract

Infections are major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes -which play a crucial role in host defence against viral infections-. are divided in subsets based upon the expression of several cell and activation markers. Since in senescence changes in peripheral blood CD8+ T lymphocyte compartment have been described, studies were performed to determine whether in aging there are variations in the peripheral blood CD8+CD38+, CD8+CD57+, CD8+HLA-DR+, CD8+CD45RA+ and CD8+CD45RO+ cell subset. A decrease in the CD8+CD45RA+ lymphocytes was observed, indicating that variations in the CD8+ compartment can take place with ageing.

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ADP-ribosyl CyclaseADP-ribosyl Cyclase 1AdultAgedAged, 80 and overAgingAntigens, CDAntigens, DifferentiationCD4-Positive T-LymphocytesCD57 AntigensCD8-Positive T-LymphocytesFemaleHLA-DR AntigensHumansImmunophenotypingLeukocyte Common AntigensMaleMembrane GlycoproteinsMiddle AgedN-Glycosyl HydrolasesJournal ArticleResearch Support, Non-U.S. Gov't

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M Ruiz, B Esparza, C Pérez, M Barranquero, E Sabino, F Merino. 1995. CD8+ T cell subsets in aging.. https://doi.org/10.3109/08820139509060715

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