Search PubMed⌕ Search

PubMed · 8484247

Taiwan Blood Donation Program: a model for development.

Abstract

In 1974, the Taiwan National Blood Program had not yet been fully developed. The volunteer donor base was less than 5% and there was no organized national structure or regulation of blood services. Following the founding of the Blood Donation Association and the Blood Services Foundation, promotion of an all-volunteer blood program, increased utilization of blood components and the standardization of laboratory methods were strategies that led to the development of the Taiwan National Blood Program. In 1991, 1,066,082 units of blood were collected in Taiwan, serving a population of about 20 million. There are currently 6 major blood centers and 13 blood stations. Blood donation is now 100% volunteer and 78% of all blood collected is separated into 10 available components. With national organization and regulation, the transition has taken 17 years and has resulted in a community-based, all-volunteer blood supply.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

S J Tsai, T D Lee. 1993. Taiwan Blood Donation Program: a model for development.. https://doi.org/10.1111/j.1423-0410.1993.tb05154.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Variable adhesion of different red blood cell products to activated vascular endothelium under flow conditions.

Red blood cells (RBCs) that have been stored prior to transfusion show increased adherence to vascular endothelium in vitro, which suggests a potential for stored blood transfusion to impede blood flow in some patients. Transfusion is often required in patients with sepsis or inflammation; however, whether activation of endothelium affects stored RBC-endothelial cell (EC) interactions is unknown. We investigated whether storage time and leukocyte content of RBC products influences the adhesion of RBCs to activated ECs. RBCs from nonleukocyte-reduced (S-RBCs), buffy-coat-poor (BCP-RBCs), and leukocyte-filtered (LF-RBCs) products and cultured EC layers were pretreated with endotoxin, tumor necrosis factor-alpha (TNF-alpha), or medium alone prior to perfusion of the RBCs across the EC layer in a continuous flow microchamber. After a single day of RBC storage, the number of adherent RBCs was increased in the endotoxin and TNF-alpha pretreated groups compared to the unactivated-control group. These differences were statistically significant for S-RBCs and LF-RBC products (P < 0.05). In contrast, there was no significant difference in RBC adherence to activated and unactivated endothelium at other time-points of RBC product storage. The strength of adhesion of stored RBCs from S-RBC products to activated ECs was not altered following treatment; however, endotoxin significantly increased the adhesive strength of LF-RBCs to endothelium. These results demonstrate that while fresh RBCs show increased adhesion to activated endothelium, storage of RBCs did not promote increased adhesion to activated endothelium. However, inflammatory conditions promote stronger adhesion of stored RBCs to ECs, which may contribute to impaired tissue perfusion in some transfusion recipients.

Blood Component Removal↗

Endotoxin apheresis for sepsis.

The principle use of apheresis in the treatment of sepsis may be summarized as the removal of toxic substances and the restoration of normal organs function. It is ideal to control the early phases of inflammatory cascade when treating sepsis by removing microbial components, such as endotoxin or peptidoglycan. This review discusses endotoxin apheresis with particular emphasis on treatment using polymyxin B immobilized fiber columns (Toraymyxin) which are used widely in Japan for endotoxin removal therapy in patients with septic shock. Lixelle and CTR which have recently been shown to remove circulating bacterial components are also included in this review.

Blood Component Removal↗