PubMed · 8419259
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J G Sweeting. 1993. Does the gallbladder secrete?. https://doi.org/10.1016/0016-5085(93)90875-d
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The absorption and scattering coefficients and reflectance spectra of ultra-high density Nannochloropsis occulata cultures were investigated in detail to identify the optical properties of the cultures and devise algorithms for remote estimation of dry cell mass in ultra-high cell density cultures. High-spectral resolution measurements of apparent absorption and attenuation as well as reflectance from 400 to 900 nm were carried out in relation to the dry weight, cell count, and pigment concentration in outdoor cultures. Indices calculated as (R(NIR) - R(red))/(R(NIR) + R(red)) and R(NIR)/R(red), in which R(NIR) is reflectance in the range from 750 to 800 nm and R(red) is reflectance in the range 670-680 nm, were used for remote assessment of dry cell mass. Remote estimation in the range 1 to 8 g/L was accomplished with an error of less than 0.66 g/L. A different index, i.e., (R(NIR) - R(red)) was employed for estimation of cell-chlorophyll concentration. This is the first report of in vivo specific absorption coefficient of chlorophyll-a and specific scattering coefficient per dry algal weight of Nannochloropsis sp., providing a basis for remote monitoring of dense phytoplankton masses.
To develop an omeprazole buccal adhesive tablet, the absorption of omeprazole solutions from human oral cavity was evaluated and the physicochemical properties such as the bioadhesive forces of various omeprazole tablet formulations composed of bioadhesive polymers and alkali materials, and the stability of omeprazole tablets in human saliva were investigated. About 23% of the administered dose was absorbed from the oral cavity at 15 min after the administration of omeprazole solutions (1 mg/15 ml). A mixture of sodium alginate and HPMC was selected as the bioadhesive additive for the omeprazole tablet. Omeprazole tablets prepared with bioadhesive polymers alone had the bioadhesive forces suitable for buccal adhesive tablets, but the stability of omeprazole in human saliva was not satisfied. Among alkali materials, only magnesium oxide could be an alkali stabilizer for omeprazole buccal adhesive tablets due to its strong waterproofing effect. Two tablets composed of [omeprazole/sodium alginate/HPMC/magnesium oxide (20/24/6/50, mg/tab)] and [(20/30/0/50, mg/tab)] were suitable for omeprazole buccal adhesive tablets which could be attached to human cheeks without collapse and could be stabilized in human saliva for at least 4 h. It was concluded that these two formulae were potential candidates for the subject of further study for the development of omeprazole buccal adhesive tablets.
The influence of elevated dietary zinc and/or selenium on the suppressive effect of cadmium on egg production in hens has not been previously established. To address this question, two models of cadmium administration were used to differentiate protective effects of zinc or selenium that may result from a reduced absorption of cadmium from those resulting from an elevated nutritional status of these minerals. First, cadmium-induced suppression of egg production was produced in White Leghorn hens using intraperitoneal injections of Cd in order to determine protective effects that result from prefeeding diets supplemented with 803 ppm Zn, 0.91 ppm Se, or their combination relative to a basal diet (control). Feeding elevated dietary selenium throughout the experiment, including a 6-day prefeeding period before Cd administration, resulted in significant protection from the egg suppression produced by 2 injections of cadmium (0.27 mg/kg each) given 1 d apart. Feeding elevated dietary zinc alone or combined with +0.91 ppm Se for a similar period did not markedly protect against cadmium-induced egg suppression. After a 0.54-mg/kg dose of Cd was administered, for a cumulative dose of 1.08 mg/kg, no significant protection was observed from any of the supplemented diets. In a second experiment, the protective effect of the same dietary treatments on the egg-suppressive effect of dietary cadmium was determined. In contrast to cadmium injection, the suppressive effect of 153 ppm dietary cadmium was not mitigated by selenium supplementation, while supplemental zinc protected against this effect of dietary cadmium regardless of the amount of selenium in the diet. There was no significant change in plasma estrogen and vitellogenin levels as a result of cadmium administration in either model, with the exception of significant reduction in both these parameters in the dietary cadmium-exposed birds fed the basal diet. Together, the data suggest that the level of dietary zinc in food sources may be more important in influencing cadmium-induced egg suppression than the nutritional status of zinc in cadmium-exposed birds. In contrast, the nutritional status of selenium in cadmium-exposed birds may have the potential to mitigate this effect, but high exposures to dietary cadmium or zinc may preclude such protection.