PubMed · 8413636
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
A Abbott. 1993-10-21. German changes face opposition.. https://doi.org/10.1038/365684b0
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
The development of recombinant techniques for the rapid cloning, expression, and characterization of cDNAs encoding antibody (Ab) subunits has revolutionized the field of antibody engineering. By fusion to heterologous protein domains, chain shuffling, and inclusion of self-assembly motifs, novel molecules such as bispecific Abs can now be generated which possess the subset of functional properties designed to fit the intended application. Rapid technological developments in phage display of peptides and proteins have led to a plethora of applications directed towards immunology and antibody engineering. Many of the problems associated with the therapeutic use of Abs are being addressed by the application of these new techniques.
The results of molecular-genetic studies performed by Russian specialists in plague research are discussed. On their basis, new concepts concerning the factors determining virulence of the plague bacterium were formulated, and certain aspects of Yersinia taxonomy were clarified.