Amniotic band sequence and limb defects: data from a population-based study.

U G Froster; P A Baird

doi:10.1002/ajmg.1320460507

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Amniotic band sequence and limb defects: data from a population-based study.

U G Froster·P A Baird

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Abstract

Cases with amniotic bands were analysed separately as part of an ongoing study of limb defects occurring among 1,213,913 liveborn infants in British Columbia during the years 1952 to 1984. A total of 24 cases with this specific condition was identified among 659 cases with limb defects. The calculated incidence for amniotic band sequence with significant limb involvement was 0.19 in 10,000 livebirths. This is a minimal incidence, as cases without defects of the limbs, but with constriction rings were not identified with this approach. Familial cases and cases with additional anomalies were found.

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Amniotic Band Syndrome British Columbia Ectromelia Female Foot Deformities, Congenital Hand Deformities, Congenital Humans Incidence Infant, Newborn Limb Deformities, Congenital Male Journal Article Research Support, Non-U.S. Gov't

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U G Froster, P A Baird. 1993-06-15. Amniotic band sequence and limb defects: data from a population-based study.. https://doi.org/10.1002/ajmg.1320460507

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PubMed2006

Extremity amniotic band syndrome in fetal lamb. I: An experimental model of limb amputation.

OBJECTIVE: The objective of the study was to reproduce severe forms of extremity amniotic bands, which result in amputation or severe lesions. STUDY DESIGN: Right limbs of 5 60-day gestational age pregnant sheep were ligated with silk suture at the infracondylar level. Left limbs were used for paired comparison. The limbs obtained from term fetuses were analyzed morphologically, radiologically, and histologically. RESULTS: The ligated limbs showed an amputation or quasiamputation. Four extremities showed a necrotic pattern and 4 an edema pattern. CONCLUSION: A model of severe extremity amniotic bands that reproduces the effect of the extremity amniotic bands in the human fetus was developed. Future applications of this new model could be an experimental study of in utero salvage of limbs affected with severe extremity amniotic bands in the ovine fetus.

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Threatened lower extremity in a neonate from a severely constricting amniotic band: a case for limb salvage after a 6-year functional follow-up.

A child presented at birth with a threatened lower limb from severe constriction band. Limb salvage was performed by emergency z-plasty reconstructions and subsequent sural nerve grafting to a fibrotic segmental deficit in the sciatic nerve. Follow-up over a 6-year period enables us to provide a favorable outlook with regard to functional use of the extremity and absence of chronic lymphedema, but she does have a significant limb length discrepancy. There is virtually no information on long-term functional outcome of such cases, although textbook teaching advises one to attempt emergency salvage of an extremity that is threatened by a severely constricting congenital amniotic band. Follow-up of our patient equips us with outcome information so that we can now better inform parents when once again faced with this problem in the neonate.

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