PubMed · 8265259
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D E Domann. 1993. Cefprozil breakpoint.. https://doi.org/10.3928/0090-4481-19931001-04
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Some coumarin 7-substituted cephalosporins and related sulfones were prepared and an antimicrobial assay was performed. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) carried out on cephalosporins showed a potential activity of some of the synthesized compounds against Gram-positive microorganisms. The tests performed on the corresponding sulfones showed no significant activity, neither as antimicrobial agents nor as inhibitors of beta-lactamase. An association of sulfone 6a with ampicillin was observed to inhibit Gram-positive microorganisms with a lower MIC than for ampicillin alone.
Capillary electrophoresis offers a new way of characterizing the interaction between surfactants and drugs. This interaction was studied using capillary zone electrophoresis (CZE). It was observed that addition of tetraalkylammonium bromide to the electrolyte buffer at different concentrations of dodecyl trimethylammonium bromide (DTAB) led to a change of the migration time (tm) and of the ionic mobility (mu) of cephalosporins. For quantitative evaluation, a physicochemical model was developed to calculate the aggregation constants (k) and the stoichiometric coefficients (m) between DTAB and cephalosporins. The relative standard deviation of the effective mobilities and of the EOF were estimated.