PubMed · 8264758
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M R Salzberg. 1994-01-20. Hyperthermia.. https://doi.org/10.1056/nejm199401203300319
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Several beta-antagonists (acebutolol, atenolol, celiprolol, labetalol, metoprolol, nadolol, propranolol) were determined in urine samples with fluorometric detection after direct injection, in less than 15 min, with a micellar mobile phase of 0.1 M sodium dodecyl sulfate (SDS), 15% propanol, and 1% triethylamine at pH 3. The limits of detection (38 criterion) were usually between 3 and 30 ng/mL. The addition of propanol and triethylamine and the reduction of the pH of the mobile phase improved the efficiency of the chromatographic peaks that was rather low in pure micellar eluents. The selection of the composition of the mobile phase was easily performed through the use of an interpretive procedure which considered the retention times and peak shapes of the beta-antagonists in six chromatograms, obtained at varying concentrations of SDS (0.05-0.15 M) and propanol (5-15% v/v). The chromatograms of urine samples from healthy volunteers, which were administered atenolol, metoprolol, and propranolol, showed only one peak for the former drug and several peaks for the other two. These peaks corresponded to the parent drug and metabolites, which indicated the partial and the extensive degradation of metoprolol and propranolol, respectively.
The NMR of the Earth's magnetic field is used for diffusion-weighted imaging of phantoms. Due to a weak Larmor field, care needs to be taken regarding the use of the usual high field assumption in calculating the effect of the applied inhomogeneous magnetic field. The usual definition of the magnetic field gradient must be replaced by a generalized formula valid when the strength of a nonuniform magnetic field and a Larmor field are comparable (J. Stepisnik, Z. Phys. Chem. 190, 51-62 (1995)). It turns out that the expression for spin echo attenuation is identical to the well-known Torrey formula only when the applied nonuniform field has a proper symmetry. This kind of problem may occur in a strong Larmor field as well as when the slow diffusion rate of particles needs an extremely strong gradient to be applied. The measurements of the geomagnetic field NMR demonstrate the usefulness of the method for diffusion and flow-weighted imaging.
A reversed-phase solid-phase extraction-gas chromatography (SPE-GC)-electron capture detection method is developed to quantitate individual rethrin residues in pyrethrum-exposed brown tree snakes. Aliquots (6 g) of homogenized snake tissue are extracted with 10 mL acetonitrile. The rethrins are recovered from the acetonitrile extract and concentrated using C8 SPE. The rethrins are eluted from the SPE column with pentane, evaporated to near dryness, and reconstituted to 1 mL with 1-propanol. Individual rethrins are quantitated using GC analysis of the 1-propanol solution. Method limits of detection for rethrins range from 0.63 to 6.51 ng/g. The mean recovery for all rethrins is 70.8% with a standard deviation of 5.7%. This method is used to successfully quantitate incurred rethrin residues in pyrethrum-exposed brown tree snakes.