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PubMed · 814937

Models for depolymerizing enzymes. Application to alpha-amylases.

J A Thoma
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AmylasesBacillus subtilisHydrolysisModels, ChemicalOligosaccharidesPolymersJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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J A Thoma. 1976. Models for depolymerizing enzymes. Application to alpha-amylases.. https://doi.org/10.1002/bip.1976.360150411

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Effects of calyculin A on amylase release in streptolysin-O permeabilized acinar cells.

The effects of the phosphatase inhibitors calyculin A and okadaic acid on amylase release from streptolysin-O permeabilized rat pancreatic acini were investigated. Both agents induced similar biphasic effects with moderate potentiation of calcium-stimulated amylase release at medium and strong inhibition at higher concentrations. Calyculin A was thirty times more potent than okadaic acid and at 100 nM totally inhibited calcium-induced amylase release while 3 microM okadaic acid reduced amylase release by 78%. 100nM calyculin A also completely inhibited GTP gamma S-potentiated amylase release and partially inhibited phorbol ester potentiated secretion. The data indicate that inhibition of a serine/threonine phosphatase, probably a type 1 phosphatase, leads to inhibition of calcium-induced amylase release in permeabilized pancreatic acini.

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