PubMed · 8119114
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F Nachbar, P Blecher, T Ruzicka. 1994-03-04. [Hyperhidrosis].. https://pubmed.ncbi.nlm.nih.gov/8119114/
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Enalapril (average dose 7,0+/-0.8 mg) was given for 12 weeks to 15 patients with preserved left ventricular (LV) systolic function who had survived large focal myocardial infarction small i, Ukrainian6 months before that. The use of enalapril was associated with 49% lessening of severity of clinical signs of heart failure (p<0.001) and 47% increase of tolerance to physical exercise. It also provided dose dependent 17.8% reduction of LV myocardial mass (p<0.05), normalization of initially "hypertrophic" type of transmitral flow, 21% lowering of LV end diastolic pressure (p<0.05) without effect on LV volume, geometry, global and local systolic function.
A simple, rapid, accurate and selective 1H NMR method was developed for quantitative determination of enalapril maleate in pharmaceutical preparations. Spectra were determined in D2O, using L-leucine as internal standard. Both synthetic mixtures and commercial dosage forms were assayed, and the results were compared to those obtained using the USP XXIV procedure and were both in close agreement.
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