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PubMed · 804019

Thyroxine binding by hepatitis B surface antigen.

A R Neurath·L Korcek·A M Prince·A Lippin·M Chen
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Abstract

Thyroxine and triiodothyronine binding sites are present on the 20-nm spherical particles associated with hepatitis B surface antigen (HBsAg). Thyroxine-treated HBsAg has a buoyant density of 1.26 g/cm-3 in CsCl and appears under the electron microscope as a hexagonal particle with a center-to-vertex distance of 10 nm. These results provoke questions concerning the origin of thyroid hormone binding sites on HBsAg and a possible relationship between thyroid status and HBsAg antigenemia in humans.

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Binding Sites, AntibodyCell MembraneCentrifugation, IsopycnicCentrifugation, ZonalElectrophoresisHepatitis B AntigensHumansMicroscopy, ElectronThyroxineThyroxine-Binding ProteinsTriiodothyronineJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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A R Neurath, L Korcek, A M Prince, A Lippin, M Chen. 1975. Thyroxine binding by hepatitis B surface antigen.. https://doi.org/10.1093/infdis%2F131.2.172

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