PubMed · 8031198
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
V P Iakovlev. [Cefmetazole].. https://pubmed.ncbi.nlm.nih.gov/8031198/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Cross-contamination is a critical issue for pharmaceutical manufacturing, especially for beta-lactam antibiotics. Thus, an analytical method for the simultaneous determination of beta-lactam antibiotics cefmetazole (CMZ) and cefpodoxime proxetil (CPDXPR) contaminants in non-beta-lactam pharmaceuticals was developed using high-performance liquid chromatography-tandem mass spectrometry. The developed method was found to be sensitive at the detection limit of 0.002 ppm for both compounds. Mean recoveries of CMZ and CPDXPR from olmesartan medoxomil (OLM) tablets were 96.7 to 102.2% and 88.9 to 94.2%, respectively. The developed method was successfully applied for the verification of CMZ and CPDXPR contamination to actually manufactured OLM tablets.
OBJECTIVE: To evaluate the antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changsha and to provide a reference for the prevention and treatment of gonorrhea. METHODS: beta-Lactamase was determined by a modified iodometric method and the susceptibility to 9 antibiotic agents was tested by the disc diffusion method in 86 isolates. RESULTS: Plasmid-mediated penicillinase-producing Neisseria gonorrhoeae and plasmid-mediated tetracycline-resistant Neisseria gonorrhoeae were 40.69% and 23.26%, respectively. Of all the 9 antibiotic agents, tetracycline, cefmetazole, penicillin, ciprofloxacin, and ofloxacin had a higher resistance and the percentages of resistance were 45.35%, 50.00%, 62.79%, 77.91%, and 87.21%, respectively. On the other hand, cefuroxime, ceftriaxone, cefepime, and spectinomycin had a higher susceptibility and the percentages of susceptibility were 77.91%, 80.23%, 86.05%, and 98.84%, respectively. CONCLUSION: Penicillin, tetracycline and fluoroquinolone can not be used as routine agents to cure gonorrhea; and spectinomycin can be used as primary medicine to cure gonorrhea in Changsha, but clinical doctors need to pay more attention to it because resistant strains have come into existence.
Explore the source record for details and available documents.