Position-based sequence weights.

S Henikoff; J G Henikoff

doi:10.1016/0022-2836(94)90032-9

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Position-based sequence weights.

S Henikoff·J G Henikoff

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Abstract

Sequence weighting methods have been used to reduce redundancy and emphasize diversity in multiple sequence alignment and searching applications. Each of these methods is based on a notion of distance between a sequence and an ancestral or generalized sequence. We describe a different approach, which bases weights on the diversity observed at each position in the alignment, rather than on a sequence distance measure. These position-based weights make minimal assumptions, are simple to compute, and perform well in comprehensive evaluations.

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Amino Acid Sequence Base Sequence Computer Simulation Databases, Factual Genetic Variation Molecular Sequence Data Sequence Alignment Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

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S Henikoff, J G Henikoff. 1994-11-04. Position-based sequence weights.. https://doi.org/10.1016/0022-2836(94)90032-9

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