PubMed · 788341
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S Tomaszunas. 1976-08-01. [Filariasis].. https://pubmed.ncbi.nlm.nih.gov/788341/
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The results of mass treatment using 50 mg diethylcarbamazine per kg body-weight followed one year later by short term selective re-treatment in a highly endemic area of Brugia timori are described. The criteria for selection of re-treatment are simple and practical for use in rural areas. The microfilaria rate by finger prick decreased from 24% to 0 and by Nuclepore filtration from 30% to 2.5%. The disease rates were also affected favourably. 88% of persons receiving the drug reacted to treatment, this percentage slightly exceeding the total filarial infection rate (71%). The prevalence, onset, duration and nature of side reactions are briefly discussed and related to the presence of microfilaraemia and disease manifestations among the study population.
The survey data of microfilarial periodicity of 2 species of filariae Brugia malayi at 4 localities, Mahang and Lampihong in South Kalimantan, Bengkulu in South Sumatra, Palolo in Central Sulwesi, and the species of Brugia timori at 2 localities, Flores and Alor Islands in Nusa Tenggara were analysed by using Aikat and Das's modified statistical method. Nine cases at Mahang and five cases at Lampihong were recognized as same group of non-periodic B. malayi and 1 case at Mahang was considered to be nocturnal subperiodic B. malayi by their parameters estimated by the wave equation, the amplitude (a), the peak hour of microfilaria density (k) the periodicity index (D) and the test of equality for comparison of two series of data. The data of 9 cases from Bengkulu and 11 cases from Palolo were similarly analysed and recognized as the nocturnal periodic type of B. malayi. The data of 5 cases from Flores Island and 5 cases from Alor Island were also recognized as the nocturanal periodic type of B. timori. Thus, in these observations the non periodic strain of Brugia malayi was detected in South Kalimantan. Further studies on the principal vectors and their bionomics should be carried out.
The distribution of human filariae in Indonesia has not changed significantly since initial reports of the disease were made in 1928. Wuchereria bancrofti and Brugia malayi are widely distributed but the newly described Brugia timori appears to be restricted to the Lesser Sunda Islands. W. bancrofti and B. timori in Indonesia are nocturnally periodic and B. malayi has nocturnally periodic and B. malayi has nocturnally periodic and nocturnally subperiodic strains.