A model for AIDS pathogenesis.

D Schenzle

doi:10.1002/sim.4780131916

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PubMed · 7846411

A model for AIDS pathogenesis.

D Schenzle

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Abstract

The idea is put forward and analysed numerically, that within an infected person HIV evolves to increase its reproductivity within the population of CD4+ cells. A mathematical model predicts initial viremia and CD4+ cell drop after HIV infection and thereafter a slow progressive decline in the number of CD4+ cells, although for an extended period HIV is kept at a relatively low level by an active immune response. The time span T until the number of CD4+ cells falls below 20 per cent of its normal value depends on several model parameters. Assuming Gaussian distributions for these parameters, the model predicts a distribution function for T which resembles the observed distribution function for the incubation period to AIDS.

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Acquired Immunodeficiency Syndrome Antibody Affinity Binding Sites, Antibody CD4 Antigens Disease Progression HIV Infections Humans Immunity, Cellular Lymphopenia Models, Biological Mutation Poisson Distribution T-Lymphocytes, Helper-Inducer Time Factors Viremia Virus Latency Virus Replication Journal Article Research Support, U.S. Gov't, P.H.S.

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D Schenzle. A model for AIDS pathogenesis.. https://doi.org/10.1002/sim.4780131916

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