PubMed · 7757550
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F Iida, A Sugenoya, S Kobayashi. 1993. [Riedel thyroiditis].. https://pubmed.ncbi.nlm.nih.gov/7757550/
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Transforming growth factor-beta (TGF-beta) is the prototype of a large family of growth regulatory factors affecting the growth and differentiation of many cell types. Their action is mediated by complex formation of type I and type II receptors, both of which are serine/threonine kinases. TGF-beta inhibitors inhibit the growth of most cell types are potent immunosuppressive agents. They also stimulate the formation of connective tissue, thus promoting wound healing. TGF-beta and TGF-beta antagonists may have potential clinical uses in the treatment of various disorders.
BACKGROUND: Foldable plate haptic silicone intraocular lenses (IOLs) were surmised to produce greater anterior capsule fibrosis than poly(methyl metacrylate) (PMMA) intraocular lenses. MATERIAL AND METHODS: A retrospective study of 34 eyes was carried out 12 to 15 months after phacoemulsification. All surgical procedures were performed by the same surgeon (M.G.) using two different techniques: 17 eyes were operated on through a temporal clear-cornea incison and implanted with a foldable plate haptic silicone IOL (STAAR AA4203); 17 eyes were operated on through a superior sclerocorneal incision and received a PMMA IOL (Kabi Pharmacia 809P). Secondary opacification of the anterior capsule was compared between the two groups. RESULTS: Seventy percent of eyes (12/17) with plate haptic silicone IOL had moderate or important anterior capsule fibrosis or shrinkage. Only 18% of eyes (3/17) with PMMA IOL presented with this complication. However, posterior capsule opacification was almost similar in both groups. CONCLUSION: Foldable plate haptic silicone IOLs seem to produce a more important anterior capsule fibrosis or shrinkage than PMMA IOL one year after phacoemulsification and saccular implantation. Although etiology is unknown, either huge contact between IOL and anterior capsule, or lack of contact between anterior and posterior capsules are hypotheses advanced. Posterior capsule opacification is similar in the two groups.
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